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pubmed-article:8788159pubmed:abstractTextSchizandrin (SZ) is one of the lignan components from Schisandra fruits. A highly sensitive and precise method for the determination of SZ in human plasma was developed involving selected-ion monitoring with gas chromatography-mass spectrometry using a fused-silica capillary column. A 0.1-ml plasma sample was used for solid-phase extraction. A good linear relationship was obtained in the concentration range studied (2.0-500 ng/ml) and the method was sufficiently accurate and precise to support clinical pharmacokinetic studies. After oral administration of SZ at a dose of 15 mg to healthy male subjects, the average value of the maximum plasma concentration of SZ was 96.1 +/- 14.1 ng/ml. The plasma concentration of this substance could be monitored for 8 h after administration.lld:pubmed
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pubmed-article:8788159pubmed:dateRevised2007-10-16lld:pubmed
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pubmed-article:8788159pubmed:articleTitleDetermination of schizandrin in human plasma by gas chromatography-mass spectrometry.lld:pubmed
pubmed-article:8788159pubmed:affiliationTsumura Central Research Laboratories, Ibaraki, Japan.lld:pubmed
pubmed-article:8788159pubmed:publicationTypeJournal Articlelld:pubmed