| pubmed-article:8787680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8787680 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8787680 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:8787680 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:8787680 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8787680 | lifeskim:mentions | umls-concept:C0065175 | lld:lifeskim |
| pubmed-article:8787680 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8787680 | pubmed:dateCreated | 1996-11-4 | lld:pubmed |
| pubmed-article:8787680 | pubmed:abstractText | Lonidamine, a dichlorinated derivative of indazole-3-carboxylic acid, was shown to play a significant role in reversing or overcoming multidrug resistance. Here, we show that exposure to 50 microg/ml of lonidamine induces apoptosis in adriamycin and nitrosourea-resistant cells (MCF-7 ADR(r) human breast cancer cell line, and LB9 glioblastoma multiform cell line), as demonstrated by sub-G1 peaks in DNA content histograms, condensation of nuclear chromatin, and internucleosomal DNA fragmentation. Moreover, we find that apoptosis is preceded by accumulation of the cells in the G0/G1 phase of the cell cycle. Interestingly, lonidamine fails to activate the apoptotic program in the corresponding sensitive parental cell lines (ADR-sensitive MCF-7 WT, and nitrosourea-sensitive LI cells) even after long exposure times. The evaluation of bcl-2 protein expression suggests that this different effect of lonidamine treatment in drug-resistant and -sensitive cell lines might not simply be due to dissimilar expression levels of bcl-2 protein. To determine whether the lonidamine-induced apoptosis is mediated by p53 protein, we used cells lacking endogenous p53 and overexpressing either wild-type p53 or dominant-negative p53 mutant. We find that apoptosis by lonidamine is independent of the p53 gene. | lld:pubmed |
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| pubmed-article:8787680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8787680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8787680 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8787680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8787680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8787680 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8787680 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:ZupiGG | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:SacchiAA | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:D'AngeloCC | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:SodduSS | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:Del BufaloDD | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:LaudonioNN | lld:pubmed |
| pubmed-article:8787680 | pubmed:author | pubmed-author:BiroccioAA | lld:pubmed |
| pubmed-article:8787680 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8787680 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8787680 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:8787680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8787680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8787680 | pubmed:pagination | 1165-73 | lld:pubmed |
| pubmed-article:8787680 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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