| pubmed-article:8782457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C1519059 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C1420556 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C1424530 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C0443211 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:8782457 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:8782457 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8782457 | pubmed:dateCreated | 1996-10-22 | lld:pubmed |
| pubmed-article:8782457 | pubmed:abstractText | Chronic intestinal inflammation induced by 2,4,6,-trinitrobenzene sulfonic acid (TNBS) is characterized by a transmural granulomatous colitis that mimics some characteristics of human Crohn's disease. Here, we show that the transcription factor NF-kappa B p65 was strongly activated in TNBS-induced colitis and in colitis of interleukin-10-deficient mice. Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS-induced colitis than single or daily administration of glucocorticoids. The data provide direct evidence for the central importance of p65 in chronic intestinal inflammation and suggest a potential therapeutic utility of p65 antisense oligonucleotides as a novel molecular approach for the treatment of patients with Crohn's disease. | lld:pubmed |
| pubmed-article:8782457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8782457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8782457 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8782457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8782457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8782457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8782457 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8782457 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:8782457 | pubmed:author | pubmed-author:StrobelMM | lld:pubmed |
| pubmed-article:8782457 | pubmed:author | pubmed-author:Meyer zum... | lld:pubmed |
| pubmed-article:8782457 | pubmed:author | pubmed-author:PetterssonSS | lld:pubmed |
| pubmed-article:8782457 | pubmed:author | pubmed-author:NeurathM FMF | lld:pubmed |
| pubmed-article:8782457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8782457 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:8782457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8782457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8782457 | pubmed:pagination | 998-1004 | lld:pubmed |
| pubmed-article:8782457 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8782457 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8782457 | pubmed:articleTitle | Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. | lld:pubmed |
| pubmed-article:8782457 | pubmed:affiliation | Laboratory of Immunology, University of Mainz, Germany. | lld:pubmed |
| pubmed-article:8782457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8782457 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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