| pubmed-article:8777721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8777721 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8777721 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:8777721 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:8777721 | lifeskim:mentions | umls-concept:C1155013 | lld:lifeskim |
| pubmed-article:8777721 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:8777721 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8777721 | pubmed:dateCreated | 1996-9-16 | lld:pubmed |
| pubmed-article:8777721 | pubmed:abstractText | Itk is a T cell protein tyrosine kinase (PTK) that, along with Btk and Tec, belongs to a family of cytoplasmic PTKs with N-terminal pleckstrin homology domains. Btk plays a critical role in B lymphocyte development. To determine whether Itk has an analogous role in T lymphocytes, we used gene targeting to prepare mice lacking expression of Itk. Such animals had decreased numbers of mature thymocytes, an effect most clearly observed in mice expressing T cell receptor (TCR) transgenes. Mature T cells from Itk-deficient mice had reduced proliferative responses to allogeneic MHC stimulation and to anti-TCR cross-linking, but responded normally to stimulation with phorbol ester plus ionomycin or with IL-2. These results provide genetic evidence that Itk is involved in T cell development and also suggest that Itk has an important role in proximal events in TCR-mediated signaling pathways. | lld:pubmed |
| pubmed-article:8777721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8777721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8777721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8777721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8777721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8777721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8777721 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8777721 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:8777721 | pubmed:author | pubmed-author:LittmanD RDR | lld:pubmed |
| pubmed-article:8777721 | pubmed:author | pubmed-author:LiaoX CXC | lld:pubmed |
| pubmed-article:8777721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8777721 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:8777721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8777721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8777721 | pubmed:pagination | 757-69 | lld:pubmed |
| pubmed-article:8777721 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8777721 | pubmed:meshHeading | pubmed-meshheading:8777721-... | lld:pubmed |
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| pubmed-article:8777721 | pubmed:meshHeading | pubmed-meshheading:8777721-... | lld:pubmed |
| pubmed-article:8777721 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8777721 | pubmed:articleTitle | Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. | lld:pubmed |
| pubmed-article:8777721 | pubmed:affiliation | Department of Microbiology and Immunology, University of California, San Francisco 94143-0414, USA. | lld:pubmed |
| pubmed-article:8777721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8777721 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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