| pubmed-article:8770708 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8770708 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8770708 | lifeskim:mentions | umls-concept:C0025306 | lld:lifeskim |
| pubmed-article:8770708 | lifeskim:mentions | umls-concept:C0005767 | lld:lifeskim |
| pubmed-article:8770708 | lifeskim:mentions | umls-concept:C0005779 | lld:lifeskim |
| pubmed-article:8770708 | lifeskim:mentions | umls-concept:C0032113 | lld:lifeskim |
| pubmed-article:8770708 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8770708 | pubmed:dateCreated | 1996-9-25 | lld:pubmed |
| pubmed-article:8770708 | pubmed:abstractText | Eight pediatric patients with fulminant meningococcemia, purpura, and disseminated intravascular cogulation who by multiple prognostic scoring systems were anticipated to have a poor outcome underwent intensive plasma exchange (IPE) or whole blood exchange (WBE) in addition to standard medical therapy. IPE/WBE was initiated shortly after admission with a mixture of both fresh frozen plasma and cryoprecipitate as the replacement solution. All IPE procedures were performed using a continuous flow system and a red cell prime. The mean fibrinogen level increased from 62 to 192 mg/dl, the prothrombin time (PT) decreased from a mean of 32.4 seconds to 15.1 seconds, and the mean activated partial thromboplastin time (APTT) decreased from 89.5 seconds to 40.1 seconds following completion of the initial IPE/WBE. There was a corresponding improvement in all coagulation factor levels but only slight improvement in antithrombin III (ATIII) and protein C levels. Seven of eight patients survived (87.5%) their initial presentation with the sole early death attributed to meningitis with cerebral edema. Mean fluid balance after the procedure was +10.8 +/- 5.87 cc/kg. There were no significant bleeding or cardiovascular complications during the procedure. There was no clinical or radiographic evidence of fluid overload after the procedure. This experience demonstrates that IPE/WBE may be conducted safely in critically ill, unstable pediatric patients and is effective in rapidly improving coagulopathy without fluid overload. | lld:pubmed |
| pubmed-article:8770708 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8770708 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770708 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8770708 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8770708 | pubmed:issn | 0733-2459 | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:KevyS VSV | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:HumphreysDD | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:KentPP | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:McManusM LML | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:GorlinJJ | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:GalackiDD | lld:pubmed |
| pubmed-article:8770708 | pubmed:author | pubmed-author:ChurchwellK... | lld:pubmed |
| pubmed-article:8770708 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8770708 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8770708 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8770708 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8770708 | pubmed:pagination | 171-7 | lld:pubmed |
| pubmed-article:8770708 | pubmed:dateRevised | 2005-7-26 | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:meshHeading | pubmed-meshheading:8770708-... | lld:pubmed |
| pubmed-article:8770708 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8770708 | pubmed:articleTitle | Intensive blood and plasma exchange for treatment of coagulopathy in meningococcemia. | lld:pubmed |
| pubmed-article:8770708 | pubmed:affiliation | Multidisciplinary intensive Care Unit, Children's Hospital, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:8770708 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8770708 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8770708 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770708 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770708 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770708 | lld:pubmed |
