pubmed-article:8765673 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8765673 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
pubmed-article:8765673 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
pubmed-article:8765673 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:8765673 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
pubmed-article:8765673 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
pubmed-article:8765673 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:8765673 | pubmed:dateCreated | 1996-11-13 | lld:pubmed |
pubmed-article:8765673 | pubmed:abstractText | Purpuromycin (1) is a natural antibiotic with a broad spectrum of activity encompassing bacteria, fungi and protozoa. A new series of derivatives of 1 was prepared by the modification or replacement of the C-4 hydroxyl group. The physico-chemical characteristics and the in vitro antimicrobial activity of these new semisynthetic purpuromycin derivatives are reported. Attachment of a variety of bulky groups to the C-4 hydroxyl group as well as acylation or mesylation of 1 gave derivatives with significantly reduced antifungal activity, while the antimicrobial activity of these derivatives against Gram-positive and Gram-negative bacteria was only slightly decreased. All compounds were inactive against Escherichia coli. The C-4 epimers showed different in vitro activity as compared with those having the natural configuration, particularly against fungi. | lld:pubmed |
pubmed-article:8765673 | pubmed:language | eng | lld:pubmed |
pubmed-article:8765673 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8765673 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8765673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8765673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8765673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8765673 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8765673 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8765673 | pubmed:month | Jul | lld:pubmed |
pubmed-article:8765673 | pubmed:issn | 0014-827X | lld:pubmed |
pubmed-article:8765673 | pubmed:author | pubmed-author:FerrariPP | lld:pubmed |
pubmed-article:8765673 | pubmed:author | pubmed-author:GoldsteinBB | lld:pubmed |
pubmed-article:8765673 | pubmed:author | pubmed-author:CiabattiRR | lld:pubmed |
pubmed-article:8765673 | pubmed:author | pubmed-author:DallanoceCC | lld:pubmed |
pubmed-article:8765673 | pubmed:author | pubmed-author:TraniAA | lld:pubmed |
pubmed-article:8765673 | pubmed:author | pubmed-author:RipamontiFF | lld:pubmed |
pubmed-article:8765673 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8765673 | pubmed:volume | 51 | lld:pubmed |
pubmed-article:8765673 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8765673 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8765673 | pubmed:pagination | 503-12 | lld:pubmed |
pubmed-article:8765673 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
pubmed-article:8765673 | pubmed:meshHeading | pubmed-meshheading:8765673-... | lld:pubmed |
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pubmed-article:8765673 | pubmed:meshHeading | pubmed-meshheading:8765673-... | lld:pubmed |
pubmed-article:8765673 | pubmed:meshHeading | pubmed-meshheading:8765673-... | lld:pubmed |
pubmed-article:8765673 | pubmed:meshHeading | pubmed-meshheading:8765673-... | lld:pubmed |
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pubmed-article:8765673 | pubmed:meshHeading | pubmed-meshheading:8765673-... | lld:pubmed |
pubmed-article:8765673 | pubmed:year | 1996 | lld:pubmed |
pubmed-article:8765673 | pubmed:articleTitle | Synthesis and antimicrobial activities of 4-purpuromycin derivatives. | lld:pubmed |
pubmed-article:8765673 | pubmed:affiliation | Centro Ricerche Lepetit, Gerenzano VA, Italy. | lld:pubmed |
pubmed-article:8765673 | pubmed:publicationType | Journal Article | lld:pubmed |