Linked Life Data

8764642

Source:http://linkedlifedata.com/resource/pubmed/id/8764642

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8764642rdf:typepubmed:Citationlld:pubmed
pubmed-article:8764642lifeskim:mentionsumls-concept:C0027882lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0019564lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0205111lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0450429lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0439640lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0206249lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C1158478lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C1705422lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0439834lld:lifeskim
pubmed-article:8764642lifeskim:mentionsumls-concept:C0521116lld:lifeskim
pubmed-article:8764642pubmed:issue15lld:pubmed
pubmed-article:8764642pubmed:dateCreated1996-10-22lld:pubmed
pubmed-article:8764642pubmed:abstractTextTrains of action potentials in hippocampal pyramidal neurons are followed by a prolonged afterhyperpolarization (AHP) lasting several seconds, which is attributable to the activation of a slow calcium-activated potassium current ((sI)AHP). Here we examine the location of (sI)AHP on CA1 pyramidal neurons by comparing it with two GABAergic inhibitory postsynaptic currents (IPSCs) with known somatic and dendritic locations. Whole-cell patch-clamp recordings were made for CA1 pyramidal neurons in acute hippocampal slices. Stepping the membrane potential at the peak of (sI)AHP produced a relaxation ("switchoff") of the AHP current with a time constant of 7.4 +/- 0.4 msec (mean +/- SEM). The switchoff time constants for somatic and dendritic GABAA IPSCs were 3.5 +/- 0.5 msec and 8.8 +/- 0.3 msec, respectively. This data, together with cable modeling, indicates that active (sI)AHP channels are distributed over the proximal dendrites within approximately 200 micrometers of the soma. Excitatory postsynaptic potentials (EPSPs) evoked in stratum (s.) radiatum had their amplitudes shunted more by the AHP than did EPSPs evoked in s. oriens, suggesting that active AHP channels are restricted to the apical dendritic tree. Blockade of the AHP during a tetanus, which in control conditions elicited a decremental short-term potentiation (STP), converted STP to long-term potentiation (LTP). Thus, activation of the AHP increases the threshold for induction of LTP. These results suggest that in addition to its established role in spike frequency adaptation, the AHP works as an adjustable gain control, variably hyperpolarizing and shunting synaptic potentials arising in the apical dendrites.lld:pubmed
pubmed-article:8764642pubmed:languageenglld:pubmed
pubmed-article:8764642pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8764642pubmed:citationSubsetIMlld:pubmed
pubmed-article:8764642pubmed:statusMEDLINElld:pubmed
pubmed-article:8764642pubmed:monthAuglld:pubmed
pubmed-article:8764642pubmed:issn0270-6474lld:pubmed
pubmed-article:8764642pubmed:authorpubmed-author:SamUUlld:pubmed
pubmed-article:8764642pubmed:authorpubmed-author:BekkersJ MJMlld:pubmed
pubmed-article:8764642pubmed:issnTypePrintlld:pubmed
pubmed-article:8764642pubmed:day1lld:pubmed
pubmed-article:8764642pubmed:volume16lld:pubmed
pubmed-article:8764642pubmed:ownerNLMlld:pubmed
pubmed-article:8764642pubmed:authorsCompleteYlld:pubmed
pubmed-article:8764642pubmed:pagination4537-42lld:pubmed
pubmed-article:8764642pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:meshHeadingpubmed-meshheading:8764642-...lld:pubmed
pubmed-article:8764642pubmed:year1996lld:pubmed
pubmed-article:8764642pubmed:articleTitleApical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: implications for the integration of long-term potentiation.lld:pubmed
pubmed-article:8764642pubmed:affiliationNeuroscience Group and the Discipline of Physiology, University of Newcastle, New South Wales, Australia.lld:pubmed
pubmed-article:8764642pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8764642pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8764642lld:pubmed