| pubmed-article:8760792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8760792 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:8760792 | lifeskim:mentions | umls-concept:C0000768 | lld:lifeskim |
| pubmed-article:8760792 | lifeskim:mentions | umls-concept:C0004364 | lld:lifeskim |
| pubmed-article:8760792 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8760792 | lifeskim:mentions | umls-concept:C0686907 | lld:lifeskim |
| pubmed-article:8760792 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8760792 | pubmed:dateCreated | 1996-9-23 | lld:pubmed |
| pubmed-article:8760792 | pubmed:abstractText | Neonatal thymectomy (NTx), especially around day 3 after birth, causes various organ-specific autoimmune diseases in mice. This report shows that: (a) T cells expressing the interleukin 2 receptor alpha chains (CD25) ontogenically begin to appear in the normal periphery immediately after day 3, rapidly increasing within 2 wk to nearly adult levels (approximately 10% of CD3+ cells, especially of CD4+ cells); (b) NTx on day 3 eliminates CD25+ T cells from the periphery for several days; inoculation immediately after NTx of CD25+ splenic T cells from syngeneic non-Tx adult mice prevents autoimmune development, whereas inoculation of CD25- T cells even at a larger dose does not; and furthermore, (c) similar autoimmune diseases can be produced in adult athymic nu/nu mice by inoculating either spleen cell suspensions from 3-d-old euthymic nu/+ mice or CD25+ cell-depleted spleen cell suspensions from older, even 1-yr-old, nu/+ mice. The CD25- populations from neonates or adults are also similar in the profile of cytokine formation. These results, taken together, indicate that one aspect of peripheral self-tolerance is maintained by CD25+ T cells that sustain potentially pathogenic self-reactive T cells in a CD25- dormant state; the thymic production of the former is developmentally programmed to begin on day 3 after birth in mice. Thus, NTx on day 3 can, at least transiently, eliminate/reduce the autoimmune-preventive CD25+ T cells, thereby leading to activation of the self-reactive T cells that have been produced before NTx. | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8760792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8760792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8760792 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8760792 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8760792 | pubmed:author | pubmed-author:TodaMM | lld:pubmed |
| pubmed-article:8760792 | pubmed:author | pubmed-author:SakaguchiSS | lld:pubmed |
| pubmed-article:8760792 | pubmed:author | pubmed-author:AsanoMM | lld:pubmed |
| pubmed-article:8760792 | pubmed:author | pubmed-author:SakaguchiNN | lld:pubmed |
| pubmed-article:8760792 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8760792 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8760792 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8760792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8760792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8760792 | pubmed:pagination | 387-96 | lld:pubmed |
| pubmed-article:8760792 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:meshHeading | pubmed-meshheading:8760792-... | lld:pubmed |
| pubmed-article:8760792 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8760792 | pubmed:articleTitle | Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. | lld:pubmed |
