| pubmed-article:8760349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8760349 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:8760349 | lifeskim:mentions | umls-concept:C0054450 | lld:lifeskim |
| pubmed-article:8760349 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:8760349 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:8760349 | lifeskim:mentions | umls-concept:C0241315 | lld:lifeskim |
| pubmed-article:8760349 | pubmed:dateCreated | 1996-9-16 | lld:pubmed |
| pubmed-article:8760349 | pubmed:abstractText | DNA synthesis was measured 16 h after stimulation of Swiss 3T3 fibroblasts in the resting phase with various growth factors (platelet-derived growth factor, fibroblast growth factor, lysophosphatidic acid and thrombin). When extracellular Ca2+ was chelated by EGTA, or when the influx of Ca2+ from outside to inside the cell was blocked by cobalt, DNA synthesis was completely inhibited. As there was no effect whatsoever on DNA synthesis when Ca2+ was chelated, or when the influx of Ca2+ was blocked up to the first 4 h after growth stimulation, it was concluded that, at an early stage, Ca2+ influx from outside to inside the cell is not related to the transition from the G1 to the S phase. A Ca2+/calmodulin-dependent protein kinase II inhibitor (KN-62) had no effect on DNA synthesis. However, cyclosporin A and FK-506, which are inhibitors of Ca2+/calmodulin-dependent protein phosphatase 2B (calcineurin), markedly inhibited DNA synthesis stimulated by all of the growth factors. These results indicate that calcineurin plays a role, not only in activation of T-cells of the immune system in the initial phase, but also in DNA synthesis in fibroblasts. It was concluded that Ca2+ influx from outside to inside the cell during the mid-to-late G1 phase, followed by calcineurin activation, is essential as a mechanism of growth signal transduction. | lld:pubmed |
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| pubmed-article:8760349 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8760349 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8760349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8760349 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8760349 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8760349 | pubmed:author | pubmed-author:ItoMM | lld:pubmed |
| pubmed-article:8760349 | pubmed:author | pubmed-author:ToyoshimaKK | lld:pubmed |
| pubmed-article:8760349 | pubmed:author | pubmed-author:AmanoHH | lld:pubmed |
| pubmed-article:8760349 | pubmed:author | pubmed-author:TomonoMM | lld:pubmed |
| pubmed-article:8760349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8760349 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8760349 | pubmed:volume | 317 ( Pt 3) | lld:pubmed |
| pubmed-article:8760349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8760349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8760349 | pubmed:pagination | 675-80 | lld:pubmed |
| pubmed-article:8760349 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8760349 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8760349 | pubmed:articleTitle | Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts. | lld:pubmed |
| pubmed-article:8760349 | pubmed:affiliation | Department of Biochemistry, Sakura Hospital, Toho University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8760349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8760349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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