| pubmed-article:8752933 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8752933 | lifeskim:mentions | umls-concept:C0042721 | lld:lifeskim |
| pubmed-article:8752933 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8752933 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:8752933 | lifeskim:mentions | umls-concept:C1444749 | lld:lifeskim |
| pubmed-article:8752933 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8752933 | pubmed:dateCreated | 1996-11-7 | lld:pubmed |
| pubmed-article:8752933 | pubmed:abstractText | Both IL-12 and IFN-gamma have been implicated as principal inducers of type 1 immune responses required for the elimination of intracellular pathogens, such as viruses. We examined the in vivo antiviral role of both cytokines during coronavirus-induced hepatitis in a mouse hepatitis virus (MHV) model. The absence of IFN-gamma function in mice with a targeted disruption of the IFN-gamma R alpha-chain gene (IFN-gamma R -/-) resulted in increased susceptibility to coronaviral hepatitis associated with augmented viral replication and increased hepatocellular injury. The mutant mice showed a type 1 lymphokine response characterized by the normal high IFN-gamma and low IL-4 production. Unlike MHV-infected wild-type mice, however, the mutant IFN-gamma R -/- mice showed no increase in IL-12 p4O gene expression, similar to that in naive animals. IL-12 treatment failed to restore host resistance in IFN-gamma R -/- mice, but significantly protected MHV-susceptible C57BL/6 mice against lethal infection, although less than IFN-gamma treatment. Mice protected by IL-12 or IFN-gamma showed resistance against an otherwise lethal second MHV infection. Our data demonstrate that despite reduced IL-12 gene expression and defective IFN-gamma R function, virus-induced IFN-gamma production can occur. Furthermore, they emphasize the pivotal antiviral role of IFN-gamma in protection against acute coronavirus-induced hepatitis. | lld:pubmed |
| pubmed-article:8752933 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8752933 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752933 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8752933 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8752933 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8752933 | pubmed:author | pubmed-author:HorzinekM CMC | lld:pubmed |
| pubmed-article:8752933 | pubmed:author | pubmed-author:SchijnsV EVE | lld:pubmed |
| pubmed-article:8752933 | pubmed:author | pubmed-author:WierdaC MCM | lld:pubmed |
| pubmed-article:8752933 | pubmed:author | pubmed-author:van HoeijMM | lld:pubmed |
| pubmed-article:8752933 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8752933 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8752933 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:8752933 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8752933 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8752933 | pubmed:pagination | 815-21 | lld:pubmed |
| pubmed-article:8752933 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:meshHeading | pubmed-meshheading:8752933-... | lld:pubmed |
| pubmed-article:8752933 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8752933 | pubmed:articleTitle | Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12. | lld:pubmed |
| pubmed-article:8752933 | pubmed:affiliation | Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. | lld:pubmed |
| pubmed-article:8752933 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:15979 | entrezgene:pubmed | pubmed-article:8752933 | lld:entrezgene |
| entrez-gene:16160 | entrezgene:pubmed | pubmed-article:8752933 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752933 | lld:pubmed |
