| pubmed-article:8738134 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C0035331 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C0288263 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8738134 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8738134 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8738134 | pubmed:dateCreated | 1996-12-3 | lld:pubmed |
| pubmed-article:8738134 | pubmed:abstractText | The traditional notion that glial cells are permeable only to potassium has been revised. For example, glia from various parts of the nervous system have calcium-permeable ion channels. Since characterization of the calcium channels in glia is limited, the purpose of this study was to determine the molecular identity and examine the functional properties of a voltage-gated calcium channel expressed by Müller cells, the predominant glia of the retina. Whole-cell and perforated-patch recordings of human Müller cells in culture revealed a high threshold voltage-activated calcium current that is blocked by dihydropyridines, but not by omega-conotoxin GVIA or omega-conotoxin MVIIC. RT-PCR of cultured human Müller cells using primers specific for the calcium channel subunits demonstrated the expression of an L-type channel composed of the alpha 1D, alpha 2 and beta 3 subunits. The alpha 2 subunit of the Müller cell calcium channel is a splice variant which is distinct from either the skeletal muscle alpha 2s or the brain alpha 2b. Our electrophysiological experiments indicate that the alpha 1D/alpha 2/beta 3 calcium channel is functionally linked with the activation of a potassium channel that may serve as one of the pathways for the redistribution by Müller cells of excess retinal potassium. | lld:pubmed |
| pubmed-article:8738134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8738134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8738134 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8738134 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8738134 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8738134 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8738134 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8738134 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8738134 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8738134 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8738134 | pubmed:issn | 0169-328X | lld:pubmed |
| pubmed-article:8738134 | pubmed:author | pubmed-author:ChiuSS | lld:pubmed |
| pubmed-article:8738134 | pubmed:author | pubmed-author:KwonO JOJ | lld:pubmed |
| pubmed-article:8738134 | pubmed:author | pubmed-author:PuroD GDG | lld:pubmed |
| pubmed-article:8738134 | pubmed:author | pubmed-author:HwangJ JJJ | lld:pubmed |
| pubmed-article:8738134 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8738134 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8738134 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8738134 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8738134 | pubmed:pagination | 41-8 | lld:pubmed |
| pubmed-article:8738134 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:meshHeading | pubmed-meshheading:8738134-... | lld:pubmed |
| pubmed-article:8738134 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8738134 | pubmed:articleTitle | Characterization of an L-type calcium channel expressed by human retinal Müller (glial) cells. | lld:pubmed |
| pubmed-article:8738134 | pubmed:affiliation | Department of Ophthalmology, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA. | lld:pubmed |
| pubmed-article:8738134 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8738134 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:776 | entrezgene:pubmed | pubmed-article:8738134 | lld:entrezgene |
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