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pubmed-article:8722535pubmed:abstractTextThe in-vitro 50% inhibitory concentrations (IC50s) of latamoxef and imipenem against a set of plasmid-mediated beta-lactamases including TEM-1, TEM-3, TEM-5 and TEM-10 were determined by an enzymatic method using nitrocefin as substrate. The IC50s of both antibiotics against extended-spectrum beta-lactamases were below 0.2 mg/L. The conventional spectrum beta-lactamase TEM-1 was not inhibited by either antibiotic at the highest concentration tested. Except for TEM-10 for which the IC50s of the two antibiotics were the same, imipenem showed significantly greater activity than latamoxef against TEM-3 and TEM-5. Clavulanic acid taken as a control demonstrated greater and wider inhibitory activity, but on the other hand it has no significant antibiotic activity.lld:pubmed
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pubmed-article:8722535pubmed:authorpubmed-author:ChewG KGKlld:pubmed
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pubmed-article:8722535pubmed:pagination697-701lld:pubmed
pubmed-article:8722535pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8722535pubmed:year1996lld:pubmed
pubmed-article:8722535pubmed:articleTitleIn-vitro evaluation of beta-lactamase inhibition by latamoxef and imipenem.lld:pubmed
pubmed-article:8722535pubmed:affiliationLaboratoire Universitaire de Thérapeutique, Service de Médecine B, Hopital Carémeau, Nimes, France.lld:pubmed
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