| pubmed-article:871220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:871220 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:871220 | lifeskim:mentions | umls-concept:C0021852 | lld:lifeskim |
| pubmed-article:871220 | lifeskim:mentions | umls-concept:C0521362 | lld:lifeskim |
| pubmed-article:871220 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:871220 | lifeskim:mentions | umls-concept:C0741847 | lld:lifeskim |
| pubmed-article:871220 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:871220 | pubmed:dateCreated | 1977-6-30 | lld:pubmed |
| pubmed-article:871220 | pubmed:abstractText | Small intestinal morphologic and biochemical changes were studied following jejuno-ileal bypass for obesity after body weight stabilization had occurred. Four patients underwent biopsy of in-continuity and bypassed jejunal and ileal segments of the small intestine 11 to 22 months after the bypass operation. Microscopically, marked mucosal villus hypertrophy of the in-continuity bowel was observed, especially in the ileum. Bypassed jejunal mucosa underwent atrophy compared with pre-bypass jejunum, whereas bypassed ileum appeared similar microscopically to pre-bypass ileum. The specific activities of mucosal disaccharidase enzymes (maltase, sucrase, lactase and trehalase) in units per mg protein remained similar to pre-bypass levels in segments of the in-continuity jejunum and the bypassed jejunum and ileum. On the other hand, elevated mucosal disaccharidase levels were measured in biopsy specimens of the in-continuity ileum. Total enzyme activity per unit length of intestine, however, was estimated to be elevated in both in-continuity jejunum and ileum secondary to mucosal villus hypertrophy. These data indicate that following small bowel bypass: (1) the in-continuity ileum undergoes greater biochemical and morphologic adaptation than the jejunum; and (2) intraluminal nutrients and chyme appear to be essential to maximal intestinal adaptation. | lld:pubmed |
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| pubmed-article:871220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:871220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:871220 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:871220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:871220 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:871220 | pubmed:issn | 0003-4932 | lld:pubmed |
| pubmed-article:871220 | pubmed:author | pubmed-author:AkhtarMM | lld:pubmed |
| pubmed-article:871220 | pubmed:author | pubmed-author:DudrickS JSJ | lld:pubmed |
| pubmed-article:871220 | pubmed:author | pubmed-author:DalyJ MJM | lld:pubmed |
| pubmed-article:871220 | pubmed:author | pubmed-author:CastroGG | lld:pubmed |
| pubmed-article:871220 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:871220 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:871220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:871220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:871220 | pubmed:pagination | 642-8 | lld:pubmed |
| pubmed-article:871220 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:871220 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:871220 | pubmed:articleTitle | Gastrointestinal adaptation following small bowel bypass for obesity. | lld:pubmed |
| pubmed-article:871220 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:871220 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:871220 | pubmed:publicationType | Case Reports | lld:pubmed |
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