| pubmed-article:8709281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8709281 | lifeskim:mentions | umls-concept:C0042760 | lld:lifeskim |
| pubmed-article:8709281 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:8709281 | lifeskim:mentions | umls-concept:C0012939 | lld:lifeskim |
| pubmed-article:8709281 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8709281 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:8709281 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8709281 | pubmed:dateCreated | 1996-9-10 | lld:pubmed |
| pubmed-article:8709281 | pubmed:abstractText | While the intracellular pool of encapsidated hepatitis B viral DNA contains genomes in all stages of DNA replication, serum-derived virions contain predominantly mature, partially duplex, circular DNA genomes. To account for this finding, Summers and Mason proposed in 1982 that virion envelopment is somehow linked to the state of genomic maturation (J. Summers and W.S. Mason, Cell 29:403-415, 1982). Core gene mutations with phenotypes consistent with this concept have previously been identified in the duck hepatitis B virus (DHBV). Here we show that DHBV polymerase mutants with altered DNA synthesis also display defects in envelopment, and we provide quantitative estimates of the magnitude of the preference for the envelopment of mature DNA. In cells transfected with wild-type DHBV DNA, immature minus-strand DNA represents 18% of the intracellular pool but only 4% of extracellular virion DNA. A point mutation in the C-terminal domain of the polymerase strongly and selectively impairs plus-strand synthesis; in this mutant, the ratio of immature to mature DNA in the intracellular pool rises to 6:1 but is reduced to 1.5:1 in released virions. A missense mutation in the polymerase active site inactivates all viral DNA synthesis but still allows efficient RNA encapsidation; in this mutant, no detectable viral nucleic acid is enveloped and released. Thus, viral DNA synthesis is absolutely required for envelopment and export, and a strong further bias exists in favor of the export of genomes that have completed minus-strand synthesis and at least initiated plus-strand synthesis. These results imply that events within the interior of the nucleocapsid can powerfully influence its interactions with external viral envelope glycoproteins. | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8709281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8709281 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8709281 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8709281 | pubmed:author | pubmed-author:GanemDD | lld:pubmed |
| pubmed-article:8709281 | pubmed:author | pubmed-author:WeiYY | lld:pubmed |
| pubmed-article:8709281 | pubmed:author | pubmed-author:TavisJ EJE | lld:pubmed |
| pubmed-article:8709281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8709281 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8709281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8709281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8709281 | pubmed:pagination | 6455-8 | lld:pubmed |
| pubmed-article:8709281 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:meshHeading | pubmed-meshheading:8709281-... | lld:pubmed |
| pubmed-article:8709281 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8709281 | pubmed:articleTitle | Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses. | lld:pubmed |
| pubmed-article:8709281 | pubmed:affiliation | Howard Hughes Medical Institute, University of California Medical Center, San Francisco 94143, USA. | lld:pubmed |
| pubmed-article:8709281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8709281 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8709281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8709281 | lld:pubmed |
