Linked Life Data

8707737

Source:http://linkedlifedata.com/resource/pubmed/id/8707737

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pubmed-article:8707737pubmed:abstractTextThe growth of 113 Candida spp. isolated prospectively from 104 HIV-positive patients treated for thrush was determined using a single concentration of 3 mg/L (10(-5) M) fluconazole relative to growth in drug free medium. Using a receiver operator characteristic curve, a relative growth in fluconazole of > or = 88% best discriminated between isolates from 56 patients who responded to treatment with fluconazole and 48 who failed to respond to 7 days, treatment with at least 100 mg/d drug with a sensitivity of 98% and a specificity of 96%. When the isolates from the eight patients with mixed infections due to both resistant and susceptible yeasts were excluded, the sensitivity and specificity both reached 100%. Relative growth of Candida spp. in a single concentration of fluconazole can therefore be used to accurately predict the clinical response to standard fluconazole treatment of thrush in patients infected with HIV.lld:pubmed
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pubmed-article:8707737pubmed:articleTitleRelative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis.lld:pubmed
pubmed-article:8707737pubmed:affiliationDepartment of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, London, UK.lld:pubmed
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pubmed-article:8707737pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8707737pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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