| pubmed-article:8691426 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C2266875 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C1134681 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:8691426 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:8691426 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8691426 | pubmed:dateCreated | 1996-8-23 | lld:pubmed |
| pubmed-article:8691426 | pubmed:abstractText | Continuing studies on modifications of potent cyclic pentapeptide endothelin (ET) receptor antagonists, represented by BQ-123, and potent linear tripeptide derivative ET receptor antagonists, represented by BQ-788, are described herein. The introduction of D-tryptophan analogues with C-2 substituents in these peptidic ET antagonists resulted in potent ET receptor antagonists with various ETA/ETB subtype selectivity. Combined ETA/ETB receptor antagonists were found in both cyclic pentapeptide and linear tripeptide series with 2-halo- and 2-methyl-D-tryptophans. In contrast, compounds with 2-cyano-D-tryptophan were ETB receptor-selective antagonists. The C-2 substituent of the D-tryptophanyl residue appeared to be very important for the discrimination of ETA/ETB subtype selectivity of the antagonists. The potent ET receptor antagonists with various ETA/ETB subtype selectivity synthesized in this study may be useful tools for elucidating the physiological and pathophysiological roles of ET and ET receptors. | lld:pubmed |
| pubmed-article:8691426 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8691426 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8691426 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8691426 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8691426 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:IshikawaKK | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:KojimaHH | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:YamakawaTT | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:AmanoYY | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:YanoMM | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:KandeJJ | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:OzakiSS | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:FukamiTT | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:IharaMM | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:FukurodaTT | lld:pubmed |
| pubmed-article:8691426 | pubmed:author | pubmed-author:NiiyamaKK | lld:pubmed |
| pubmed-article:8691426 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8691426 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:8691426 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:8691426 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8691426 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8691426 | pubmed:pagination | 2313-30 | lld:pubmed |
| pubmed-article:8691426 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:meshHeading | pubmed-meshheading:8691426-... | lld:pubmed |
| pubmed-article:8691426 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8691426 | pubmed:articleTitle | Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity. | lld:pubmed |
| pubmed-article:8691426 | pubmed:affiliation | Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Company, Ltd., Ibaraki, Japan. | lld:pubmed |
| pubmed-article:8691426 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8691426 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:8691426 | lld:chembl |
