| pubmed-article:8690925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0005768 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:8690925 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:8690925 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8690925 | pubmed:dateCreated | 1996-8-26 | lld:pubmed |
| pubmed-article:8690925 | pubmed:abstractText | We have previously reported a preferential usage of V delta 1/V gamma 8 on TCR-gamma-delta-bearing intraepithelial lymphocytes of the normal human intestine as well as in the inflamed synovial tissue of patients with rheumatoid arthritis. The aim of the present study was to analyze V gene segment usage by gamma delta T cells of the intestine and peripheral blood (PB) from patients with inflammatory bowel disease. Freshly isolated lymphocytes were analyzed by flow cytometry using a panel of V gene subset-specific mAbs. The relative proportion of PB TCR-gamma delta+ cells was increased in patients with Crohn's disease as compared with controls. Interestingly, an increased proportion of PB gamma delta T cells of patients with ulcerative colitis or CrD expressed V delta and V gamma genes typically used by intraepithelial lymphocytes. Thus, increased proportions of V delta 1+ and V gamma 8+ cells were found in the PB of both patient groups. The majority of TCR-gamma delta+ intraepithelial lymphocytes (IEL) in inflamed and noninflamed intestine expressed V delta 1/V gamma 8, and a substantial proportion of V gamma(2,3,4)+ cells were found. These observations suggest a disease-associated appearance of "gut-like" gamma delta T cells in the periphery. Moreover, two patients had a large proportion of gamma delta T cells in their PB of which the majority expressed two distinct V gamma proteins. Both of these patients had a short duration of disease (1 and 10 mo, respectively) and the relative proportion of gamma delta T cells decreased in concert with stabilization of disease. Interestingly, one of the patients had a clonal expansion of a V gamma dual-expressing gamma delta T cell in the PB. | lld:pubmed |
| pubmed-article:8690925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8690925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690925 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8690925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8690925 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8690925 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8690925 | pubmed:author | pubmed-author:MagnussonII | lld:pubmed |
| pubmed-article:8690925 | pubmed:author | pubmed-author:KiesslingRR | lld:pubmed |
| pubmed-article:8690925 | pubmed:author | pubmed-author:HalapiEE | lld:pubmed |
| pubmed-article:8690925 | pubmed:author | pubmed-author:GrönbergAA | lld:pubmed |
| pubmed-article:8690925 | pubmed:author | pubmed-author:BuchtAA | lld:pubmed |
| pubmed-article:8690925 | pubmed:author | pubmed-author:SöderströmKK | lld:pubmed |
| pubmed-article:8690925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8690925 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8690925 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:8690925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8690925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8690925 | pubmed:pagination | 2331-9 | lld:pubmed |
| pubmed-article:8690925 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:meshHeading | pubmed-meshheading:8690925-... | lld:pubmed |
| pubmed-article:8690925 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8690925 | pubmed:articleTitle | Increased frequency of abnormal gamma delta T cells in blood of patients with inflammatory bowel diseases. | lld:pubmed |
| pubmed-article:8690925 | pubmed:affiliation | Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:8690925 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8690925 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8690925 | lld:pubmed |
