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| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:8690454 | lifeskim:mentions | umls-concept:C0376518 | lld:lifeskim |
| pubmed-article:8690454 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8690454 | pubmed:dateCreated | 1996-8-29 | lld:pubmed |
| pubmed-article:8690454 | pubmed:abstractText | A chronic viral infection can occur when the host fails to mount an effective immune response to clear the virus. Mouse hepatitis virus type 3 (MHV3) appears to be an excellent model for the study of the relationship between viral-induced immunodeficiency and chronic disease development. (C57BL/6 x A/J)F1 mice surviving acute hepatitis develop a chronic disease characterized by T- and B-cell immunodeficiencies, viral persistence in various organs including the brain, spleen and thymus, and death within 3 months postinfection (p.i.). We have reported that T- or B-cell deficiencies, observed in MHV3 chronically infected (C57BL/6 x A/J)F1 mice, can be partially or totally thwarted by adoptive transfer of CD4+, CD8+ and/or B cells, at 15 days p.i. in mice surviving the acute phase of the disease. Adoptive transfer of syngeneic CD4+ and/or CD8+ allowed a partial restoration of the T-cell deficiencies, as characterized by thymic atrophy, decrease in splenic T cells, and in all thymocyte subpopulations. B-cell immunodeficiency, as defined by a decrease in splenic B cells, as well as in the bone marrow pre-B- and B-cell compartments, and the occurrence of abnormally larger forms of bone marrow pre-B and B cells, were partially thwarted by B-cell treatment only. Splenic B cells and the bone marrow B-cell compartment, respectively, returned partially or totally to normal values, whereas the pre-B-cell compartment remained depleted in infected mice treated with B cells. Levels of all immunoglobulin classes returned to normal values in MHV3 chronically infected mice when treated with CD4+ in combination with CD8+ cells. All T- and/or B-cell treatments, however, were sufficient to thwart the process of the chronic disease, and favoured the survival of mice for up to 6 months p.i. | lld:pubmed |
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| pubmed-article:8690454 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8690454 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690454 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8690454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8690454 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8690454 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8690454 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8690454 | pubmed:author | pubmed-author:JolicoeurPP | lld:pubmed |
| pubmed-article:8690454 | pubmed:author | pubmed-author:MenezesJJ | lld:pubmed |
| pubmed-article:8690454 | pubmed:author | pubmed-author:LamontagneLL | lld:pubmed |
| pubmed-article:8690454 | pubmed:author | pubmed-author:DecarieDD | lld:pubmed |
| pubmed-article:8690454 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8690454 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:8690454 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8690454 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8690454 | pubmed:pagination | 220-9 | lld:pubmed |
| pubmed-article:8690454 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8690454 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8690454 | pubmed:articleTitle | Effect of adoptive transfer of CD4, CD8 and B cells on recovery from MHV3-induced immunodeficiencies. | lld:pubmed |
| pubmed-article:8690454 | pubmed:affiliation | Dépt Sciences Biologiques, Université du Québec à Montréal, Canada. | lld:pubmed |
| pubmed-article:8690454 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8690454 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8690454 | lld:pubmed |
