| pubmed-article:8674160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8674160 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:8674160 | lifeskim:mentions | umls-concept:C1515654 | lld:lifeskim |
| pubmed-article:8674160 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8674160 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8674160 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8674160 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8674160 | pubmed:dateCreated | 1996-8-15 | lld:pubmed |
| pubmed-article:8674160 | pubmed:abstractText | The antimetabolite 1-beta-D-arabinofuranosyl-cytosine (ara-C) has proven to be one of the most effective agents available for the treatment of acute leukemia. While ara-C has been implicated as a potent inhibitor of mammalian cell DNA replication, the specific mechanism by which ara-C kills cells is not known. In this report we describe the development of an in vitro model system to study the molecular mechanism of ara-CMP incorporation into DNA. This model system makes use of a recently described human cell multiprotein DNA replication complex (MRC) that is competent to replicate DNA in vitro. The MRC can successfully incorporate ara-CMP into replicating DNA at internucleotide positions. These results are similar to those described for studies using intact cells. This MRC-driven in vitro replication system may therefore serve as a powerful model for the study of anticancer agents that directly affect human cell DNA synthesis. | lld:pubmed |
| pubmed-article:8674160 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8674160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8674160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8674160 | pubmed:issn | 0344-5704 | lld:pubmed |
| pubmed-article:8674160 | pubmed:author | pubmed-author:RossDD | lld:pubmed |
| pubmed-article:8674160 | pubmed:author | pubmed-author:HickeyRR | lld:pubmed |
| pubmed-article:8674160 | pubmed:author | pubmed-author:MalkasLL | lld:pubmed |
| pubmed-article:8674160 | pubmed:author | pubmed-author:WillsPP | lld:pubmed |
| pubmed-article:8674160 | pubmed:author | pubmed-author:CuddyDD | lld:pubmed |
| pubmed-article:8674160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8674160 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:8674160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8674160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8674160 | pubmed:pagination | 366-72 | lld:pubmed |
| pubmed-article:8674160 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:meshHeading | pubmed-meshheading:8674160-... | lld:pubmed |
| pubmed-article:8674160 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8674160 | pubmed:articleTitle | A novel in vitro model system for studying the action of ara-C. | lld:pubmed |
| pubmed-article:8674160 | pubmed:affiliation | University of Maryland School of Medicine, Department of Pharmacology and Experimental Therapeutics, Baltimore, MD 21201, USA. | lld:pubmed |
| pubmed-article:8674160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8674160 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8674160 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8674160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
