| pubmed-article:8668179 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C0872184 | lld:lifeskim |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C0084785 | lld:lifeskim |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:8668179 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8668179 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8668179 | pubmed:dateCreated | 1996-8-8 | lld:pubmed |
| pubmed-article:8668179 | pubmed:abstractText | Thyroid transcription factor 1 (TTF-1), hepatocyte nuclear factor 3alpha (HNF-3alpha), and HNF-3beta regulate the transcription of genes expressed in the respiratory epithelium. To test whether members of the HNF-3/forkhead family influence TTF-1 gene expression, deletion constructs containing the 5' region of the human TTF-1 gene were transfected into immortalized mouse lung epithelial (MLE) cells. DNase I protection and electrophoretic mobility shift assays identified elements in the 5' region of the TTF-1 gene that bound MLE cell nuclear proteins consistent with the binding of HNF-3 to sites at positions -135 to -124 and -14 to -3. In MLE cells, TTF-1-luciferase reporter constructs were activated by cotransfection with HNF-3beta, activated to a lesser extent by HNF-3alpha, but not activated by HFH-8. HNF-3alpha. and HFH-8 inhibited the activation of TTF-1-luciferase by HNF-3beta. Site-specific mutagenesis of each of the HNF-3 binding sites in the human TTF-1 gene inhibited the binding of MLE cell nuclear proteins and inhibited transactivation of the TTF-1-luciferase constructs after cotransfection with HNF-3beta. Immunohistochemical staining demonstrated that both HNF-3beta and TTF-1 were detected in bronchiolar and alveolar type II cells in the human lung. Modulation of TTF-1 gene expression by members of the HNF-3/forkhead family members may provide a mechanism by which distinct HNF-3/forkhead family members influence respiratory epithelial cell gene expression and cell differentiation. | lld:pubmed |
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| pubmed-article:8668179 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8668179 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8668179 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8668179 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8668179 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8668179 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8668179 | pubmed:author | pubmed-author:IkedaKK | lld:pubmed |
| pubmed-article:8668179 | pubmed:author | pubmed-author:WhitsettJ AJA | lld:pubmed |
| pubmed-article:8668179 | pubmed:author | pubmed-author:WertS ESE | lld:pubmed |
| pubmed-article:8668179 | pubmed:author | pubmed-author:Shaw-WhiteJ... | lld:pubmed |
| pubmed-article:8668179 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8668179 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:8668179 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8668179 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8668179 | pubmed:pagination | 3626-36 | lld:pubmed |
| pubmed-article:8668179 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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