| pubmed-article:8666906 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:8666906 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:8666906 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8666906 | pubmed:dateCreated | 1996-8-5 | lld:pubmed |
| pubmed-article:8666906 | pubmed:abstractText | The function of murine dendritic epidermal cells (dEC) remains largely speculative, probably because of the lack of a suitable in vivo model, although previous studies suggest that gamma/delta+ dEC may have originally evolved to serve as a self-protection mechanism(s). Our previous study demonstrated that the epidermis of mice that had spontaneously recovered from cutaneous graft-vs-host disease (GVHD) induced by local injection of CD4+ autoreactive T cells contained unexpectedly large numbers of dEC and became resistant to subsequent attempts to induce GVHD in a site-restricted manner, suggesting that the resistance is mediated by dEC. However, because alpha/beta+ dEC as well as gamma/delta+ dEC were greatly increased in number in the epidermis, it was unclear whether gamma/delta+ dEC are indeed responsible for this protection. The availability of this murine model and mice selectively lacking gamma/delta T cells as a result of disruption of the T cell receptor C delta gene segment allowed us to investigate the role of gamma/delta+ dEC. In the epidermis of gamma/delta T cell-deficient mice (delta-/-), a congenital lack of gamma/delta+ dEC was substituted for by alpha/beta+ dEC of either a CD4-8+ or a CD4-8- phenotype. After intradermal injection of the autoreactive T cells, delta-/- mice developed significantly enhanced delayed-type hypersensitivity responses and cutaneous GVHD, which persisted longer than in heterozygous littermate controls (delta+/-). Surprisingly, resistance to the cutaneous GVHD was not induced in the epidermis of delta-/- mice after spontaneous recovery from the GVHD, whereas the "susceptible" epidermis of delta-/+ mice contained large numbers of alpha/beta dEC comparable to those in "resistant" epidermis of delta+/- mice. Injection of day 16 fetal thymocytes from wild-type mice into delta-/- mice resulted in the appearance of donor-type gamma/delta+ dEC in the epidermis, and reconstitution with gamma/delta+ dEC restored the protective immune response of the epidermis against the GVHD to nearly normal levels. These results indicate that gamma/delta+ dEC are responsible for the site-restricted protection against cutaneous GVHD. | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8666906 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8666906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666906 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8666906 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8666906 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8666906 | pubmed:author | pubmed-author:HayakawaJJ | lld:pubmed |
| pubmed-article:8666906 | pubmed:author | pubmed-author:IshikawaHH | lld:pubmed |
| pubmed-article:8666906 | pubmed:author | pubmed-author:MoriyaNN | lld:pubmed |
| pubmed-article:8666906 | pubmed:author | pubmed-author:ItoharaSS | lld:pubmed |
| pubmed-article:8666906 | pubmed:author | pubmed-author:ShioharaTT | lld:pubmed |
| pubmed-article:8666906 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8666906 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8666906 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:8666906 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8666906 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8666906 | pubmed:pagination | 1483-9 | lld:pubmed |
| pubmed-article:8666906 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:meshHeading | pubmed-meshheading:8666906-... | lld:pubmed |
| pubmed-article:8666906 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8666906 | pubmed:articleTitle | Resistance to cutaneous graft-vs.-host disease is not induced in T cell receptor delta gene-mutant mice. | lld:pubmed |
| pubmed-article:8666906 | pubmed:affiliation | Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8666906 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8666906 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:110066 | entrezgene:pubmed | pubmed-article:8666906 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666906 | lld:pubmed |
