| pubmed-article:8640821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C1334306 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C1655807 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8640821 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:8640821 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8640821 | pubmed:dateCreated | 1996-7-15 | lld:pubmed |
| pubmed-article:8640821 | pubmed:abstractText | Inhibition of tumor neovascularization has profound effects on the growth of solid tumors. An endothelial cell-specific cytotoxic conjugate was prepared by chemically linking recombinant vascular endothelial growth factor (VEGF165) and a truncated diphtheria toxin molecule (DT385). The treatment of subconfluent cultures of human umbilical vein endothelial cells and human microvascular endothelial cells with the VEGF165-DT385 conjugate resulted in a selective, dose-dependent inhibition of growth. Parallel experiments with either the free toxin or a mixture of VEGF and the toxin polypeptide did not affect proliferation (DNA synthesis) of these cells. The selective cytotoxicity correlated with the appropriate receptor expression (KDR/flk-1 positive) on the target cells. VEGF-toxin conjugate inhibited the growth of a murine hemangioma-derived endothelial cell line (Py-4-1), which was positive for flk-1 expression. Under similar conditions, the conjugate did not affect the proliferation of a receptor-negative ovarian cancer cell line in vitro. In an in vivo model of angiogenesis, the VEGF165-DT385 conjugate blocked basic fibroblast growth factor-induced neovascularization of the chick chorioallantoic membrane. These studies demonstrate the successful targeting of a cytotoxic polypeptide to proliferating vascular endothelial cells (normal and tumorigenic) and the potential utility of such conjugates in blocking tumor neovascularization. | lld:pubmed |
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| pubmed-article:8640821 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8640821 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8640821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8640821 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8640821 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8640821 | pubmed:author | pubmed-author:RamakrishnanS... | lld:pubmed |
| pubmed-article:8640821 | pubmed:author | pubmed-author:BautchV LVL | lld:pubmed |
| pubmed-article:8640821 | pubmed:author | pubmed-author:OlsonT ATA | lld:pubmed |
| pubmed-article:8640821 | pubmed:author | pubmed-author:MohanrajDD | lld:pubmed |
| pubmed-article:8640821 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8640821 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8640821 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8640821 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8640821 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8640821 | pubmed:pagination | 1324-30 | lld:pubmed |
| pubmed-article:8640821 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8640821 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8640821 | pubmed:articleTitle | Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. | lld:pubmed |
| pubmed-article:8640821 | pubmed:affiliation | Department of Pharmacology, University of Minnesota, Minneapolis, 55455, USA. | lld:pubmed |
| pubmed-article:8640821 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8640821 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8640821 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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