| pubmed-article:8639809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:8639809 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8639809 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8639809 | pubmed:dateCreated | 1996-7-16 | lld:pubmed |
| pubmed-article:8639809 | pubmed:abstractText | T cells with antidonor specificities have been isolated from human recipients experiencing graft rejection after allogeneic bone marrow transplantation (BMT). Partial T-cell depletion of unrelated BM grafts with an anti- T-cell receptor (TCR) monoclonal antibody (MoAb) directed against the TCR alpha/beta heterodimer have shown that the incidence of graft-versus-host disease is low and that the incidence of durable engraftment is high. These studies suggest either that the number of residual TCR alpha/beta+ cells was sufficient to permit alloengraftment or that the preservation of cells other than TCR alpha/beta+ cells was beneficial for engraftment. With respect to the latter, one such candidate cell is the TCR gamma/delta+ T cell. Because no studies have specifically examined whether TCR gamma/delta+ cells might be capable of eliminating BM-derived hematopoietic cells, we established a new graft rejection model system in which transgenic (Tg) H-2d mice (termed G8), known to express gamma/delta heterodimers on high proportion of peripheral T cells, were used as BMT recipients. These Tg TCR gamma/delta+ cells respond vigorously to target cells that express the nonclassical major histocompatibility complex (MHC) class lb region gene products encoded in H-2T region of H-2T(b)+ strains. G8 Tg mice were used as recipients for C57BL/6 (B6: H-2(b); H-2T(b)) T-cell-depleted (TCD) donor BM. We show that G8 Tg (H-2(d), H-2T(d)) mice are potent mediators of B6 BM graft rejection and that the rejection process was inhibited by anti-TCR gamma/delta MoAbs. In contrast, BM from a B6 congenic strain that expresses the H-2T(a) allele, B6.A-Tl(a)/BoyEg, was readily accepted, suggesting that H-2T antigens on repopulating donor BM cells are the targets of host graft rejecting T cells that express the TCR gamma/delta heterodimer. PB chimerism studies were performed at > or = 1.5 months post-BMT using TCD BM from severe combined immunodeficient allogeneic donors, which is highly susceptible to rejection by the host. The addition of donor G8 TCR gamma/delta+ cells to TCD donor BM was shown to significantly increase alloengraftment in B6 recipients. These results show that (1) host TCR gamma/delta+ cells can reject repopulating donor cells, presumably by responding to nonclassical MHC class lb gene products expressed on BM-derived hematopoietic progenitor cells; and (2) donor TCR gamma/delta+ cells can facilitate the alloengraftment of rigorously TCD donor BM. | lld:pubmed |
| pubmed-article:8639809 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8639809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8639809 | pubmed:month | May | lld:pubmed |
| pubmed-article:8639809 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8639809 | pubmed:author | pubmed-author:BluestoneJ... | lld:pubmed |
| pubmed-article:8639809 | pubmed:author | pubmed-author:ValleraD ADA | lld:pubmed |
| pubmed-article:8639809 | pubmed:author | pubmed-author:TaylorP APA | lld:pubmed |
| pubmed-article:8639809 | pubmed:author | pubmed-author:BlazarB RBR | lld:pubmed |
| pubmed-article:8639809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8639809 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8639809 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:8639809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8639809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8639809 | pubmed:pagination | 4463-72 | lld:pubmed |
| pubmed-article:8639809 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8639809 | pubmed:meshHeading | pubmed-meshheading:8639809-... | lld:pubmed |
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| pubmed-article:8639809 | pubmed:meshHeading | pubmed-meshheading:8639809-... | lld:pubmed |
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| pubmed-article:8639809 | pubmed:meshHeading | pubmed-meshheading:8639809-... | lld:pubmed |
| pubmed-article:8639809 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8639809 | pubmed:articleTitle | Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens. | lld:pubmed |
| pubmed-article:8639809 | pubmed:affiliation | Department of Pediatrics, University of Minnesota Hospital, Minneapolis, USA. | lld:pubmed |
| pubmed-article:8639809 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8639809 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8639809 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8639809 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
