| pubmed-article:8631917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8631917 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:8631917 | lifeskim:mentions | umls-concept:C0016677 | lld:lifeskim |
| pubmed-article:8631917 | lifeskim:mentions | umls-concept:C0001109 | lld:lifeskim |
| pubmed-article:8631917 | lifeskim:mentions | umls-concept:C1561491 | lld:lifeskim |
| pubmed-article:8631917 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8631917 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:8631917 | pubmed:dateCreated | 1996-7-1 | lld:pubmed |
| pubmed-article:8631917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8631917 | pubmed:abstractText | Acid phosphatases (Acp) of intracellular pathogens have recently been implicated as virulence factors that enhance intracellular survival through suppression of the respiratory burst. We describe here the identification, purification, characterization, and sequencing of a novel burst-inhibiting acid phosphatase from the facultative intracellular bacterium, Francisella tularensis. Similar to other the burst-inhibiting Acps, F. tularensis Acp (AcpA) is tartrate-resistant and has broad substrate specificity. The AcpA enzyme is unique, however, in that it is easily released from the bacterial cell in soluble form, is a basic enzyme, suppresses the respiratory burst of not only fMet-Leu-Phe but also phorbol 12-myristate 13-acetate-stimulated neutrophils and does not fit into any of the three currently recognized classes of acid phosphatase. We also report the complete nucleotide sequence of the gene acpA, encoding AcpA, and the deduced primary structure of its encoded polypeptide. Comparative sequence analyses of AcpA is discussed. To our knowledge, this is the first report describing the cloning and sequencing of a burst-inhibiting acid phosphatase. | lld:pubmed |
| pubmed-article:8631917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8631917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8631917 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8631917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8631917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8631917 | pubmed:month | May | lld:pubmed |
| pubmed-article:8631917 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8631917 | pubmed:author | pubmed-author:Kuhlenschmidt... | lld:pubmed |
| pubmed-article:8631917 | pubmed:author | pubmed-author:NanoF EFE | lld:pubmed |
| pubmed-article:8631917 | pubmed:author | pubmed-author:ReillyT JTJ | lld:pubmed |
| pubmed-article:8631917 | pubmed:author | pubmed-author:BaronG SGS | lld:pubmed |
| pubmed-article:8631917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8631917 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:8631917 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8631917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8631917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8631917 | pubmed:pagination | 10973-83 | lld:pubmed |
| pubmed-article:8631917 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8631917 | pubmed:meshHeading | pubmed-meshheading:8631917-... | lld:pubmed |
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| pubmed-article:8631917 | pubmed:meshHeading | pubmed-meshheading:8631917-... | lld:pubmed |
| pubmed-article:8631917 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8631917 | pubmed:articleTitle | Characterization and sequencing of a respiratory burst-inhibiting acid phosphatase from Francisella tularensis. | lld:pubmed |
| pubmed-article:8631917 | pubmed:affiliation | Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA. | lld:pubmed |
| pubmed-article:8631917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8631917 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8631917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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