| pubmed-article:8619846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8619846 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8619846 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8619846 | lifeskim:mentions | umls-concept:C0042036 | lld:lifeskim |
| pubmed-article:8619846 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:8619846 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:8619846 | lifeskim:mentions | umls-concept:C0243175 | lld:lifeskim |
| pubmed-article:8619846 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8619846 | pubmed:dateCreated | 1996-6-13 | lld:pubmed |
| pubmed-article:8619846 | pubmed:abstractText | A potent inhibitor of the Na-K-Cl cotransport system was purified from urines of salt-loaded rats. Mass spectroscopy revealed a molecular mass of 242 Da. Nuclear magnetic resonance showed a spectrum identical to that of 3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol (an "estrogen-like" isoflavonoid: equol). This compound inhibited cotransport fluxes at similar concentrations (IC50=16-24 microM) as furosemide (IC50 approximately 10 microM). Cotransport inhibitory activity of urines from rats drinking tap water was fully explained by urinary equol concentrations (approximately 27 microM, measured by high-performance liquid chromatography). Slat-loading increased urinary equol excretion, but not sufficiently high to fully explain the very important increase in cotransport inhibitory potency. We conclude that: (i) under basal conditions urinary equol can regulate Na-K-Cl cotransport activity in the kidney and (ii) salt-loading should evoke the appearance of other cotransport inhibitors. | lld:pubmed |
| pubmed-article:8619846 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8619846 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8619846 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8619846 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8619846 | pubmed:author | pubmed-author:OsL OLO | lld:pubmed |
| pubmed-article:8619846 | pubmed:author | pubmed-author:GarbeR WRW | lld:pubmed |
| pubmed-article:8619846 | pubmed:author | pubmed-author:MartinezR MRM | lld:pubmed |
| pubmed-article:8619846 | pubmed:author | pubmed-author:AldaJ OJO | lld:pubmed |
| pubmed-article:8619846 | pubmed:author | pubmed-author:GimenezII | lld:pubmed |
| pubmed-article:8619846 | pubmed:author | pubmed-author:MayoralJ AJA | lld:pubmed |
| pubmed-article:8619846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8619846 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8619846 | pubmed:volume | 221 | lld:pubmed |
| pubmed-article:8619846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8619846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8619846 | pubmed:pagination | 279-85 | lld:pubmed |
| pubmed-article:8619846 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8619846 | pubmed:meshHeading | pubmed-meshheading:8619846-... | lld:pubmed |
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| pubmed-article:8619846 | pubmed:meshHeading | pubmed-meshheading:8619846-... | lld:pubmed |
| pubmed-article:8619846 | pubmed:meshHeading | pubmed-meshheading:8619846-... | lld:pubmed |
| pubmed-article:8619846 | pubmed:meshHeading | pubmed-meshheading:8619846-... | lld:pubmed |
| pubmed-article:8619846 | pubmed:meshHeading | pubmed-meshheading:8619846-... | lld:pubmed |
| pubmed-article:8619846 | pubmed:meshHeading | pubmed-meshheading:8619846-... | lld:pubmed |
| pubmed-article:8619846 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8619846 | pubmed:articleTitle | Purification and chemical characterization of a potent inhibitor of the Na-K-Cl cotransport system in rat urine. | lld:pubmed |
| pubmed-article:8619846 | pubmed:affiliation | Physiology and Pharmacology, School of Medicine, University of Zaragoza, Spain. | lld:pubmed |
| pubmed-article:8619846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8619846 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8619846 | lld:pubmed |
