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pubmed-article:8601313pubmed:abstractTextOlfactory signaling is initiated by interactions between odorants and olfactory receptors. We show that the C. elegans odr-10 gene is likely to encode a receptor for the odorant diacetyl. odr-10 mutants have a specific defect in chemotaxis to diacetyl, one of several odorants detected by the AWA olfactory neurons. odr-10 encodes a predicted seven transmembrane domain receptor; a green fluorescent protein-tagged Odr-10 protein is localized to the AWA sensory cilia. odr-10 expression is regulated by odr-7, a transcription factor implicated in AWA sensory specification. Expression of odr-10 from a heterologous promoter directs behavioral responses to diacetyl, but not to another odorant detected by the AWA neurons. These results provide functional evidence for a specific interaction between an olfactory receptor protein and its odorant ligand.lld:pubmed
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pubmed-article:8601313pubmed:pagination899-909lld:pubmed
pubmed-article:8601313pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:8601313pubmed:articleTitleodr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl.lld:pubmed
pubmed-article:8601313pubmed:affiliationHoward Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, University of California, San Francisco, 94143-0452, USA.lld:pubmed
pubmed-article:8601313pubmed:publicationTypeJournal Articlelld:pubmed
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