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pubmed-article:8572875pubmed:abstractTextInhaled nitric oxide, a selective pulmonary vasodilator, reverses hypoxic pulmonary vasoconstriction and is an effective treatment in some cases of human pulmonary hypertension. Localization of nitric oxide synthase had indicated a neural role for nitric oxide. Thus, we studied the interactions between inhaled nitric oxide and systemic and pulmonary vascular reactivity in acute neurogenic hypertension. In 6 male beagle dogs (mean weight: 15 +/- 1 kg), anesthetized by chloralose (8 cg/kg) and in spontaneous ventilation, the hemodynamic effects on systemic and pulmonary circulation of inhaled nitric oxide (12 ppm) were studied before and after acute sino-aortic denervation. The hemodynamic effects of intravenous propranolol (300 micrograms/kg) were studied after denervation. Mean arterial pressure (MAP), pulmonary capillary pressure (PCP), mean arterial pulmonary pressure (MAPP), cardiac input (CI) and oxygen venous saturation (SvO2) were measured. [table: see text] Sino-aortic denervation causes an acute and transitory pulmonary hypertension due to a double mechanism: a post-capillary hypertension (increase PCP) secondary to an increase left ventricular post-charge by systemic hypertension and a precapillary hypertension. In fact, vascular pulmonary resistances increase from 1.8 +/- 0.1 to 3.4 +/- 0.8 uW after denervation (p < 0.05). Change in pulmonary vascular reactivity induced by catecholamines is probably involved. Propranolol but not inhaled nitric oxide reverse pulmonary hypertension due to sino-aortic denervation.lld:pubmed
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pubmed-article:8572875pubmed:pagination1209-12lld:pubmed
pubmed-article:8572875pubmed:dateRevised2009-2-13lld:pubmed
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pubmed-article:8572875pubmed:year1995lld:pubmed
pubmed-article:8572875pubmed:articleTitle[Absence of the effect of nitric oxide on pulmonary and systemic hypertension induced by sino-aortic denervation].lld:pubmed
pubmed-article:8572875pubmed:affiliationService de cardiologie et de chirurgie cardiovasculaire, Hôpital Rangueil, Toulouse.lld:pubmed
pubmed-article:8572875pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8572875pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8572875pubmed:publicationTypeEnglish Abstractlld:pubmed