| pubmed-article:8570642 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8570642 | lifeskim:mentions | umls-concept:C0080298 | lld:lifeskim |
| pubmed-article:8570642 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:8570642 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:8570642 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:8570642 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8570642 | pubmed:dateCreated | 1996-3-1 | lld:pubmed |
| pubmed-article:8570642 | pubmed:abstractText | We have compared the tumorigenicity of two src oncogenes, v-src and c-src(527), whose respective protein products pp60v-src and pp60c-src(527) show a different spectrum of amino acid substitutions vis-à-vis the c-src protooncogene-encoded product pp60c-src. Whereas the extent of primary tumor growth induced by c-src(527) was quite similar in the two chicken lines tested, the extent of v-src-induced tumor growth showed a marked line dependence. As examined with a line of chickens that shows immune-mediated regression of v-src-induced tumors, a weaker tumor immunity, as correlated with a greater level of primary tumor growth, resulted from inoculation of c-src(527) DNA than of v-src DNA. These observations indicated that the v-src-specific amino acid substitutions define a major tumor antigenicity. That a separate src-associated antigenicity is also targetable by the tumor immune response followed from the finding that the level of protective immunity against the growth of c-src(527) DNA-induced tumors was augmented under conditions of the prior regression of v-src DNA-induced tumors. As this latter antigenicity may include one or more c-src(527)-encoded peptides that are equivalent to c-src-encoded self peptides, these observations suggest that a host tolerance to pp60c-src can be broken so as to permit a tumor immune response based on recognition of self peptides of pp60c-src(527). | lld:pubmed |
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| pubmed-article:8570642 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8570642 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8570642 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8570642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8570642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8570642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8570642 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8570642 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8570642 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8570642 | pubmed:author | pubmed-author:HalpernM SMS | lld:pubmed |
| pubmed-article:8570642 | pubmed:author | pubmed-author:EnglandJ MJM | lld:pubmed |
| pubmed-article:8570642 | pubmed:author | pubmed-author:TaylorR LRLJr | lld:pubmed |
| pubmed-article:8570642 | pubmed:author | pubmed-author:KopenG CGC | lld:pubmed |
| pubmed-article:8570642 | pubmed:author | pubmed-author:ChristouA AAA | lld:pubmed |
| pubmed-article:8570642 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8570642 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:8570642 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8570642 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8570642 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8570642 | pubmed:pagination | 824-7 | lld:pubmed |
| pubmed-article:8570642 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:meshHeading | pubmed-meshheading:8570642-... | lld:pubmed |
| pubmed-article:8570642 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8570642 | pubmed:articleTitle | Endogenous c-src as a determinant of the tumorigenicity of src oncogenes. | lld:pubmed |
| pubmed-article:8570642 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Medical College of Pennsylvania, Philadelphia, USA. | lld:pubmed |
| pubmed-article:8570642 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8570642 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
