| pubmed-article:8548834 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8548834 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:8548834 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8548834 | lifeskim:mentions | umls-concept:C0017349 | lld:lifeskim |
| pubmed-article:8548834 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:8548834 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8548834 | lifeskim:mentions | umls-concept:C0063356 | lld:lifeskim |
| pubmed-article:8548834 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8548834 | pubmed:dateCreated | 1996-2-20 | lld:pubmed |
| pubmed-article:8548834 | pubmed:abstractText | Induction of T-helper cells and T-B cell interaction have been considered to critically depend upon recognition of major histocompatibility complex (MHC) class II molecules by the T cell receptor. Mice lacking either MHC class II molecules (class II(0/0) mice) or its associated invariant chain (Ii0/0 mice) provide new opportunities to test this premise. Immune responses to some protein antigens have been studied in these mice; little is known about their ability to withstand viral infections. We therefore tested CD8+ effector T cells and CD4+ T-cell-dependent B cell function during different viral infections. The vesicular stomatitis virus (VSV)-specific primary cytotoxic T cell response which is largely T-helper-dependent was diminished in Ii(0/0) and absent in class II(0/0) mice. The usually less T-helper-dependent cytotoxic vaccinia or lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cell responses were reduced up to ninefold in class II(0/0) and up to threefold in Ii(0/0) mice. In class II(0/0) mice, the T-helper-independent neutralizing IgM response against the glycoprotein of VSV was within normal ranges but, in contrast to previous results on CD4(0/0) mice, the T-helper-dependent IgG response was absent. Ii(0/0) mice exhibited a normal neutralizing IgM response; in contrast to class II(0/0) mice, they mounted a significant, though reduced specific IgG response. Similar results were obtained for antibody responses against the nucleoprotein of VSV. Although the T-helper-cell response upon infection with VSV seemed diminished only a little in Ii(0/0) mice, presentation of VSV-G to a class II-restricted specific hybridoma was greater than 300-fold reduced in the absence of Ii. This suggests that local protein concentrations reached during viral infection in the host are high enough to override the Ii deficiency of antigen-presenting cells in vivo. | lld:pubmed |
| pubmed-article:8548834 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8548834 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8548834 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8548834 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8548834 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:ZinkernagelR... | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:HengartnerHH | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:BenoistCC | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:MathisDD | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:BattegayMM | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:VivilleSS | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:BachmannM FMF | lld:pubmed |
| pubmed-article:8548834 | pubmed:author | pubmed-author:BurhkartCC | lld:pubmed |
| pubmed-article:8548834 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8548834 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:8548834 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:8548834 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8548834 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8548834 | pubmed:pagination | 115-21 | lld:pubmed |
| pubmed-article:8548834 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:meshHeading | pubmed-meshheading:8548834-... | lld:pubmed |
| pubmed-article:8548834 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8548834 | pubmed:articleTitle | Antiviral immune responses of mice lacking MHC class II or its associated invariant chain. | lld:pubmed |
| pubmed-article:8548834 | pubmed:affiliation | Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland. | lld:pubmed |
| pubmed-article:8548834 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8548834 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14961 | entrezgene:pubmed | pubmed-article:8548834 | lld:entrezgene |
| entrez-gene:16149 | entrezgene:pubmed | pubmed-article:8548834 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8548834 | lld:pubmed |
