| pubmed-article:8546219 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C0027720 | lld:lifeskim |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:8546219 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:8546219 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8546219 | pubmed:dateCreated | 1996-2-12 | lld:pubmed |
| pubmed-article:8546219 | pubmed:abstractText | Interferon-inducible protein (IP)-10 is a small glycoprotein member of a family of chemotactic cytokines structurally related to interleukin-8. We have recently described the induction of IP-10 mRNA in mouse mesangial cells stimulated with lipopolysacharide, interferon-gamma, and tumor necrosis factor-alpha. To further evaluate a possible role for this chemokine in renal injury, we have studied IP-10 in an experimental model of nephrosis induced in rats by adriamycin. High levels of glomerular IP-10 mRNA expression and glomerular and tubulointerstitial IP-10 protein were seen on day 21, coinciding with maximal proteinuria, glomerular tumor necrosis factor mRNA expression, and interstitial cellular infiltrates. Maintenance on a low protein diet not only delayed the appearance of proteinuria and interstitial cellular infiltrate but also decreased glomerular IP-10 mRNA expression. Isolated normal glomeruli and cultured glomerular epithelial and mesangial cells from normal rats expressed IP-10 mRNA upon stimulation with 100 U/ml interferon or 1 microgram/ml lipopolysaccharide for 3 hours. IP-10 mRNA expression was also inducible by lipopolysaccharide and cytokines in NRK 49F renal interstitial fibroblasts and, to a lesser extent, in NRK 52E tubular epithelial cells. Furthermore, IP-10 protein was inducible in murine mesangial cells. We conclude that IP-10 is highly inducible in vitro and in vivo in resident glomerular and tubulointerstitial cells. IP-10 may participate in the modulation of renal damage in experimental nephrosis. | lld:pubmed |
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| pubmed-article:8546219 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8546219 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8546219 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8546219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8546219 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8546219 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8546219 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:GonzálezEE | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:BaratAA | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:EgidoJJ | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:HamiltonT ATA | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:OrtizAA | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:PlazaJ JJJ | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:EmancipatorS... | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:SerónDD | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:Gómez-Chiarri... | lld:pubmed |
| pubmed-article:8546219 | pubmed:author | pubmed-author:González-Cuad... | lld:pubmed |
| pubmed-article:8546219 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8546219 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:8546219 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8546219 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8546219 | pubmed:pagination | 301-11 | lld:pubmed |
| pubmed-article:8546219 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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