| pubmed-article:8537695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8537695 | lifeskim:mentions | umls-concept:C0242402 | lld:lifeskim |
| pubmed-article:8537695 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8537695 | lifeskim:mentions | umls-concept:C0027796 | lld:lifeskim |
| pubmed-article:8537695 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:8537695 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:8537695 | lifeskim:mentions | umls-concept:C1283188 | lld:lifeskim |
| pubmed-article:8537695 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8537695 | pubmed:dateCreated | 1996-2-7 | lld:pubmed |
| pubmed-article:8537695 | pubmed:abstractText | Long-term intraspinal infusions of opioid drugs are being increasingly utilized in patients with noncancer pain. Despite this, there is a lack of long-term information, including success and failure rates for pain relief and technical problems. During a 5-year period, 18 noncancer patients underwent implantation of programmable infusion pumps for long-term intrathecal opioid infusion. Patients had (a) neuropathic pain, (b) had failed or been ineligible for noninvasive treatments, and (c) obtained greater than 50% pain relief with intrathecal trial infusions of morphine sulfate or sufentanil citrate. A disinterested third-party reviewer evaluated patients at the most recent follow-up. Sixty-one percent (11/18) of patients had good or fair pain relief with mean follow-up 2.4 +/- 0.3 years (0.8-4.7 years). Average numeric pain scores decreased by 39% +/- 4.3%. Five of the 11 responders required lower opioid doses (12-24 mg/day morphine) and the remaining six patients required higher opioid doses (> 34 mg/day morphine). Failure of long-term pain relief occurred in 39% (7/18) despite good pain relief in trial infusions and the use of both morphine and sufentanil. Technical problems developed in 6/18 patients but appeared to be preventable with further experience. Long-term intrathecal opioid infusions can be effective in treatment of neuropathic pain but might require higher infusion doses. | lld:pubmed |
| pubmed-article:8537695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8537695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8537695 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8537695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8537695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8537695 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8537695 | pubmed:issn | 0885-3924 | lld:pubmed |
| pubmed-article:8537695 | pubmed:author | pubmed-author:Stanton-Hicks... | lld:pubmed |
| pubmed-article:8537695 | pubmed:author | pubmed-author:HassenbuschS... | lld:pubmed |
| pubmed-article:8537695 | pubmed:author | pubmed-author:CovingtonE... | lld:pubmed |
| pubmed-article:8537695 | pubmed:author | pubmed-author:WaliaI SIS | lld:pubmed |
| pubmed-article:8537695 | pubmed:author | pubmed-author:GuthreyD SDS | lld:pubmed |
| pubmed-article:8537695 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8537695 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8537695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8537695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8537695 | pubmed:pagination | 527-43 | lld:pubmed |
| pubmed-article:8537695 | pubmed:dateRevised | 2006-8-15 | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:meshHeading | pubmed-meshheading:8537695-... | lld:pubmed |
| pubmed-article:8537695 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8537695 | pubmed:articleTitle | Long-term intraspinal infusions of opioids in the treatment of neuropathic pain. | lld:pubmed |
| pubmed-article:8537695 | pubmed:affiliation | Department of Neurosurgery, Anderson Cancer Center, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:8537695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8537695 | pubmed:publicationType | Clinical Trial | lld:pubmed |
