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pubmed-article:8537104pubmed:abstractTextThe IgG subclass responses to antigens incorporated in liposomes containing lipid A were investigated using a synthetic malarial antigen (SPf66) and cholera toxin (CT). The antigen-specific IgG subclass response was determined in BALB/c mice immunized with either: (a) SPf66 encapsulated in liposomes containing lipid A, (b) CT bound to the surface of liposomes containing lipid A, or (c) both encapsulated SPf66 and surface-bound CT in the same liposomes. In each case the antibodies to SPf66, CT and lipid A demonstrated an IgG2a predominance. Liposomes containing lipid A not only increased the magnitude of the antibody response to liposomal antigens but elicited predominantly IgG2a subclass antibodies as well.lld:pubmed
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pubmed-article:8537104pubmed:articleTitleMurine IgG subclass antibodies to antigens incorporated in liposomes containing lipid A.lld:pubmed
pubmed-article:8537104pubmed:affiliationDepartment of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.lld:pubmed
pubmed-article:8537104pubmed:publicationTypeJournal Articlelld:pubmed
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