| pubmed-article:8518210 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C0002006 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:8518210 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8518210 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8518210 | pubmed:dateCreated | 1993-7-27 | lld:pubmed |
| pubmed-article:8518210 | pubmed:abstractText | Infusion of endothelin-1 (ET-1) into rats increased adrenal mitochondrial synthesis of aldosterone from deoxycorticosterone and the adrenal cytosolic content of aldosterone. The dose-response relationships for these last two effects of ET-1 were found to be biphasic with a maximum (corresponding to 80 to 200% increase) at 50 to 80 ng ET-1/kg/min, and were also dependent on the infusion rate. Plasma aldosterone levels were also increased in a similar ratio. Previous infusion of the converting enzyme inhibitor enalapril did not affect the ET-1-induced increase in steroidogenesis. Finally, pregnenolene production was also increased in incubations of mitochondria from treated rats. These results indicate that ET-1 augments aldosteronogenesis by increasing the early as well as the late pathway. These effects were independent of the formation of angiotensin II. Isolated glomerulosa cells responded to ET-1 increasing aldosterone production in a dose-related fashion. These results confirm a direct effect of ET-1 on the adrenal gland in vivo. | lld:pubmed |
| pubmed-article:8518210 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8518210 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8518210 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8518210 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8518210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8518210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8518210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8518210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8518210 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8518210 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8518210 | pubmed:issn | 0960-0760 | lld:pubmed |
| pubmed-article:8518210 | pubmed:author | pubmed-author:LantosC PCP | lld:pubmed |
| pubmed-article:8518210 | pubmed:author | pubmed-author:Gomez-Sanchez... | lld:pubmed |
| pubmed-article:8518210 | pubmed:author | pubmed-author:CozzaE NEN | lld:pubmed |
| pubmed-article:8518210 | pubmed:author | pubmed-author:PecciAA | lld:pubmed |
| pubmed-article:8518210 | pubmed:author | pubmed-author:de BednersM... | lld:pubmed |
| pubmed-article:8518210 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8518210 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8518210 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8518210 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8518210 | pubmed:pagination | 555-61 | lld:pubmed |
| pubmed-article:8518210 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:meshHeading | pubmed-meshheading:8518210-... | lld:pubmed |
| pubmed-article:8518210 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8518210 | pubmed:articleTitle | In vivo stimulation of aldosterone biosynthesis by endothelin: loci of action and effects of doses and infusion rate. | lld:pubmed |
| pubmed-article:8518210 | pubmed:affiliation | Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. | lld:pubmed |
| pubmed-article:8518210 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8518210 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8518210 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
