| pubmed-article:8508266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0001349 | lld:lifeskim |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0033522 | lld:lifeskim |
| pubmed-article:8508266 | lifeskim:mentions | umls-concept:C0439234 | lld:lifeskim |
| pubmed-article:8508266 | pubmed:dateCreated | 1993-7-9 | lld:pubmed |
| pubmed-article:8508266 | pubmed:abstractText | Studies on the relationship between acute-phase protein (APP) production, clinical disease activity and progression of radiological damage in RA have been hampered by three factors: patients are studied at different stages of the disease; APP levels are taken incidentally rather than serially; and inter-individual differences in the relationship between the extent of the acute-phase reaction and the progression of radiological damage are not accounted for. A group of 110 newly diagnosed (complaints < 1 year) patients with RA were analysed for a follow-up period of at least three years. Damage was assessed radiologically according to the modified method of Sharp. As radiological progression is a cumulative event, APP production was also calculated by plotting serial CRP levels over time. Overall, a highly significant correlation was found between CRP production and radiological progression; however, a wide variation was observed due to inter-individual differences. The greatest variation was found in the lower range of CRP values, where inter-individual variation could not be accounted for by HLA-DR4, positive RF, sex or age. In conclusion, the prognostic use of serial measurement of APPs for the assessment of radiological progression is limited due to inter-individual variation. Knowledge of the factors underlying these inter-individual differences will increase the applicability of CRP in the prediction of joint damage for individual patients. | lld:pubmed |
| pubmed-article:8508266 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8508266 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8508266 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8508266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8508266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8508266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8508266 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8508266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8508266 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8508266 | pubmed:issn | 0263-7103 | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:HoutmanP MPM | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:LimburgP CPC | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:van RielP LPL | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:Te MeermanG... | lld:pubmed |
| pubmed-article:8508266 | pubmed:author | pubmed-author:van De... | lld:pubmed |
| pubmed-article:8508266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8508266 | pubmed:volume | 32 Suppl 3 | lld:pubmed |
| pubmed-article:8508266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8508266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8508266 | pubmed:pagination | 9-13 | lld:pubmed |
| pubmed-article:8508266 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:meshHeading | pubmed-meshheading:8508266-... | lld:pubmed |
| pubmed-article:8508266 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8508266 | pubmed:articleTitle | The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: a prospective study during the first three years of the disease. | lld:pubmed |
| pubmed-article:8508266 | pubmed:affiliation | Department of Rheumatology, University Hospital, Groningen, The Netherlands. | lld:pubmed |
| pubmed-article:8508266 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8508266 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8508266 | lld:pubmed |
