| pubmed-article:8506948 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0108788 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0108789 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:8506948 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:8506948 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8506948 | pubmed:dateCreated | 1993-7-8 | lld:pubmed |
| pubmed-article:8506948 | pubmed:abstractText | Subsets of T cells express different isoforms of the leukocyte common antigen CD45; those expressing the glycoprotein 220 isoform (CD45RA) have been characterized as naive in their response to antigens, and those expressing the glycoprotein 180 isoform (CD45RO) as memory T cells. The association between the rejection status of human cardiac allograft recipients and the relative infiltration of the CD45 subsets of both CD8+ and CD4+ T cells was examined using two-color immunohistological labeling techniques on 33 heart transplant biopsies, categorized by routine histological and clinical criteria as mild (requiring no treatment) or moderate (requiring antirejection therapy) rejection. Double-labeling was performed using pairs of monoclonal antibodies to define the following populations: CD4+ CD45RA+, CD4+ CD45RO+, CD8+ CD45RA+, and CD8+-CD45RO+. The number of cells per high-power field (HPF) for each of these cell subsets was counted in every biopsy. In cases with mild rejection, infiltration was predominant for CD4+ CD45RA+ cells (median = 5.0 cells/HPF) relative to CD4+ CD45RO+ (3.12 cells/HPF), CD8+ CD45RA+ (2.14 cells/HPF), and especially CD8+ CD45RO+ (1.22 cells/HPF) populations. In cases with moderate rejection, all four subpopulations increased but were essentially equivalent in intensity, such that in comparison to cases with mild rejection, the smallest increase was seen for CD4+ CD45RA+ cells (6.67 cells/HPF, P < 0.09) and the greatest for CD8+ CD45RO+ cells (7.00 cells/HPF, P < 0.002). A majority of CD8 cells expressed CD45RA in 14 of 16 (88%) cases of mild rejection compared to only 2 of 17 cases of moderate rejection. Moreover, the ratio of CD45RO+ to CD45RA+ cells in each biopsy was higher in moderate versus mild rejection for both CD4 (median ratios = 1.13 versus 0.68, respectively; P < 0.008) and CD8 (1.43 versus 0.58, respectively; P < 0.005) subsets. A majority of T cells expressed CD45RO in cases of moderate rejection (11 of 14 or 79%), compared to only 1 of 13 (8%) cases of mild rejection. These findings indicate that during generally self-limited mild acute cardiac allograft rejection there is a predominance of naive CD45RA+ T cells, especially of the CD4 phenotype, whereas during moderate rejection there is a significant shift toward activated CD45RO+ T cells, especially in the CD8 population. | lld:pubmed |
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| pubmed-article:8506948 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8506948 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8506948 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8506948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8506948 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8506948 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8506948 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:8506948 | pubmed:author | pubmed-author:SanfilippoFF | lld:pubmed |
| pubmed-article:8506948 | pubmed:author | pubmed-author:IbrahimSS | lld:pubmed |
| pubmed-article:8506948 | pubmed:author | pubmed-author:DawsonD VDV | lld:pubmed |
| pubmed-article:8506948 | pubmed:author | pubmed-author:Van TrigtPP | lld:pubmed |
| pubmed-article:8506948 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8506948 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:8506948 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8506948 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8506948 | pubmed:pagination | 1794-803 | lld:pubmed |
| pubmed-article:8506948 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8506948 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8506948 | pubmed:articleTitle | Differential infiltration by CD45RO and CD45RA subsets of T cells associated with human heart allograft rejection. | lld:pubmed |
| pubmed-article:8506948 | pubmed:affiliation | Department of Pathology, Duke University, Durham, North Carolina. | lld:pubmed |
| pubmed-article:8506948 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8506948 | pubmed:publicationType | Comparative Study | lld:pubmed |
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