| pubmed-article:8499633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8499633 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8499633 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8499633 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8499633 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8499633 | pubmed:dateCreated | 1993-7-1 | lld:pubmed |
| pubmed-article:8499633 | pubmed:abstractText | Human interleukin-10 (IL-10) inhibits T-cell proliferation and cytokine production in the presence of monocytes. In this study, we have investigated whether IL-10 can directly inhibit T cells. Highly purified peripheral blood T cells containing less than 0.1% CD14+ cells and unresponsive to phytohemagglutinin (PHA), were growth-inhibited by IL-10 when stimulated with immobilized OKT3 monoclonal antibody (MoAb; 55.4% inhibition). This effect was neutralized by the murine MoAb 19F1 directed against human IL-10. In addition, IL-10 inhibited by 52.5% the proliferation of a human tetanus toxoid-specific T-cell clone (TM11) induced by immobilized OKT3 MoAb in the absence of antigen-presenting function. T-cell growth inhibition by IL-10 did not reflect a cytokine-induced change in the kinetics of T-cell response to immobilized OKT3 MoAb, and was observed over a wide range of cell and OKT3 MoAb concentrations. Addition of 1% to 5% monocytes to highly purified peripheral blood T cells resulted in the emergence of proliferation to PHA and to soluble OKT3 MoAb, but did not significantly affect levels of growth inhibition by IL-10 in the presence of immobilized OKT3 MoAb. Similarly, addition of 10% monocytes to the TM11 T-cell clone resulted in the emergence of proliferation in response to tetanus toxoid, but did not significantly influence growth inhibition by IL-10 in the presence of immobilized OKT3 MoAb. When stimulated with immobilized OKT3 MoAb in the absence of accessory cells, T cells secreted IL-2. Secretion of IL-2 under these conditions was inhibited by IL-10 (51.5% inhibition). Thus, IL-10 can directly inhibit growth and IL-2 production in T cells triggered by immobilized OKT3 MoAb in the absence of monocytes. | lld:pubmed |
| pubmed-article:8499633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8499633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8499633 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8499633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8499633 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8499633 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8499633 | pubmed:author | pubmed-author:TosatoGG | lld:pubmed |
| pubmed-article:8499633 | pubmed:author | pubmed-author:TagoYY | lld:pubmed |
| pubmed-article:8499633 | pubmed:author | pubmed-author:MostowskiHH | lld:pubmed |
| pubmed-article:8499633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8499633 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8499633 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:8499633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8499633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8499633 | pubmed:pagination | 2964-71 | lld:pubmed |
| pubmed-article:8499633 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8499633 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8499633 | pubmed:articleTitle | Human interleukin-10 can directly inhibit T-cell growth. | lld:pubmed |
| pubmed-article:8499633 | pubmed:affiliation | Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:8499633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8499633 | pubmed:publicationType | In Vitro | lld:pubmed |
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