| pubmed-article:8491817 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0034417 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0005889 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C1521806 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0008269 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:8491817 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:8491817 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8491817 | pubmed:dateCreated | 1993-6-16 | lld:pubmed |
| pubmed-article:8491817 | pubmed:abstractText | A high-performance liquid chromatographic method with fluorescence detection is described for the simultaneous measurement of quinine, chloroquine and mono- and bidesethylchloroquine in human plasma, erythrocytes and urine. After a liquid-solid extraction on a Bond Elut C8 cartridge, the compounds are separated on an Inertsil silica column by gradient elution; the mobile phase is a mixture of acetonitrile and methanol-25% ammonia solution (92.7:7.5, v/v). The eluent was monitored with a fluorescence detector (excitation wavelength 325 nm and emission wavelength 375 nm). The limit of detection was ca. 5 ng/ml for chloroquine and ca. 23 ng/ml for quinine. No chromatographic interferences could be detected from endogenous compounds or other antimalarial drugs. The method is accurate with inter- and intra-assay coefficients of variation lower than 7%. Hydroxychloroquine is used as an internal standard because of its structural similarity to chloroquine. The procedure requires 30 min and can be used for therapeutic drug monitoring. | lld:pubmed |
| pubmed-article:8491817 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8491817 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8491817 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8491817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8491817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8491817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8491817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8491817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8491817 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8491817 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8491817 | pubmed:issn | 0021-9673 | lld:pubmed |
| pubmed-article:8491817 | pubmed:author | pubmed-author:BrazierJ LJL | lld:pubmed |
| pubmed-article:8491817 | pubmed:author | pubmed-author:RobelAA | lld:pubmed |
| pubmed-article:8491817 | pubmed:author | pubmed-author:ChauletJ FJF | lld:pubmed |
| pubmed-article:8491817 | pubmed:author | pubmed-author:SoaresOO | lld:pubmed |
| pubmed-article:8491817 | pubmed:author | pubmed-author:PrevostoJ MJM | lld:pubmed |
| pubmed-article:8491817 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8491817 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:8491817 | pubmed:volume | 613 | lld:pubmed |
| pubmed-article:8491817 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8491817 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8491817 | pubmed:pagination | 303-10 | lld:pubmed |
| pubmed-article:8491817 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:meshHeading | pubmed-meshheading:8491817-... | lld:pubmed |
| pubmed-article:8491817 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8491817 | pubmed:articleTitle | Simultaneous determination of chloroquine and quinine in human biological fluids by high-performance liquid chromatography. | lld:pubmed |
| pubmed-article:8491817 | pubmed:affiliation | Laboratoire de Biochimie du Professeur Lemontey, Hôpital d'Instruction des Armées Desgenettes, Lyon, France. | lld:pubmed |
| pubmed-article:8491817 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8491817 | lld:pubmed |
