| pubmed-article:8471428 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C0025196 | lld:lifeskim |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C0004565 | lld:lifeskim |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C0243126 | lld:lifeskim |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8471428 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8471428 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8471428 | pubmed:dateCreated | 1993-5-14 | lld:pubmed |
| pubmed-article:8471428 | pubmed:abstractText | The cellular distribution of 4-borono-2-[18F]fluoro-L-phenylalanine ([18F]FBPA, an analog of p-boronophenylaline), a potential agent for boron neutron capture therapy (BNCT), and [6-3H]thymidine ([3H]Thd, a DNA precursor) in murine two B16 melanoma sublines and FM3A mammary carcinoma was studied in vivo using double-tracer microautoradiography. Tumour volume, tumour age, cell density in the tissues and the proportion of S phase cells in the cell cycle were the same in the three tumour models. Volume doubling time, which represents tumour growth rate, was fastest in B16F10, followed by B16F1 (P < 0.05), the slowest being in FM3A (P < 0.001). The rate of DNA synthesis in S phase cells corresponded to the volume doubling time. The greatest amount of [18F]FBPA was observed in S phase melanocytes and the lowest amount was found in non-S phase non-melanocytes. The [18F]FBPA accumulation was primarily related to the activity of DNA synthesis and, secondarily, to the degree of pigmentation in melanocytes. The therapeutic efficacy of BNCT with p-boronophenylalanine may be greater in melanoma that exhibits greater DNA synthesis activity and higher melanin content. | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8471428 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471428 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8471428 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8471428 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:8471428 | pubmed:author | pubmed-author:YamadaSS | lld:pubmed |
| pubmed-article:8471428 | pubmed:author | pubmed-author:TadaMM | lld:pubmed |
| pubmed-article:8471428 | pubmed:author | pubmed-author:IshiwataKK | lld:pubmed |
| pubmed-article:8471428 | pubmed:author | pubmed-author:KubotaKK | lld:pubmed |
| pubmed-article:8471428 | pubmed:author | pubmed-author:IdeJJ | lld:pubmed |
| pubmed-article:8471428 | pubmed:author | pubmed-author:KubotaRR | lld:pubmed |
| pubmed-article:8471428 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8471428 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:8471428 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8471428 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8471428 | pubmed:pagination | 701-5 | lld:pubmed |
| pubmed-article:8471428 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:meshHeading | pubmed-meshheading:8471428-... | lld:pubmed |
| pubmed-article:8471428 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8471428 | pubmed:articleTitle | Cellular accumulation of 18F-labelled boronophenylalanine depending on DNA synthesis and melanin incorporation: a double-tracer microautoradiographic study of B16 melanomas in vivo. | lld:pubmed |
| pubmed-article:8471428 | pubmed:affiliation | Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan. | lld:pubmed |
| pubmed-article:8471428 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8471428 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
