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pubmed-article:8452112pubmed:abstractTextBetween June 1977 and April 1983 the Radiation Therapy Oncology Group (RTOG) sponsored a Phase III randomized trial investigating the use of fast neutron radiotherapy for patients with locally advanced (Stages C and D1) adenocarcinoma of the prostate gland. Patients were randomized to receive either conventional photon radiation or fast neutron radiation used in a mixed-beam (neutron/photon) treatment schedule. A total of 91 analyzable patients were entered into the study, and the two patient groups were balanced with respect to the major prognostic variables. Actuarial curves are presented for local/regional control and "overall" survival. Ten-year results for clinically assessed local control are 70% for the mixed-beam group versus 58% for the photon group (p = 0.03) and for survival are 46% for the mixed-beam group versus 29% for the photon group (p = 0.04). This study suggests that a regional method of treatment can influence both local tumor control and survival in patients with locally advanced adenocarcinoma of the prostate gland.lld:pubmed
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pubmed-article:8452112pubmed:pagination164-7lld:pubmed
pubmed-article:8452112pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8452112pubmed:articleTitleFast neutron radiotherapy for locally advanced prostate cancer. Final report of Radiation Therapy Oncology Group randomized clinical trial.lld:pubmed
pubmed-article:8452112pubmed:affiliationDepartment of Radiation Oncology, University of Washington Medical Center, Seattle 98195.lld:pubmed
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pubmed-article:8452112pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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