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pubmed-article:8422555pubmed:abstractTextCollagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes V beta 8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete V beta 6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 466B5 treated animals was not significantly different from controls. Thus, the V beta 8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.lld:pubmed
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pubmed-article:8422555pubmed:articleTitlePrevention of collagen induced arthritis in mice by deletion of T cell receptor V beta 8 bearing T cells with monoclonal antibodies.lld:pubmed
pubmed-article:8422555pubmed:affiliationDepartment of Rheumatology, Mayo Clinic, Rochester, MN 55905.lld:pubmed
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