| pubmed-article:8413246 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C0521324 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C0001998 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:8413246 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8413246 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8413246 | pubmed:dateCreated | 1993-10-26 | lld:pubmed |
| pubmed-article:8413246 | pubmed:abstractText | The rat aldolase A gene contains two alternative promoters and two alternative first exons. The distal promoter M is expressed at a high level only in skeletal muscle. Previous in vitro transfection studies identified the region from -202 to -85 as an enhancer that is responsible for dramatic activation during the differentiation of chicken primary myoblasts. This enhancer contains an A/T-rich sequence resembling the MEF-2 motif, which is an important element of muscle enhancers and promoters. In this study, we demonstrate that the MEF-2 sequence is essential but not sufficient for the activity of the enhancer. Another region required for the activity was recognized by a nuclear factor, tentatively named MAF1. MAF1 was found in both muscle cells and nonmuscle cells, and MAF1 from both cell types was indistinguishable by gel retardation and DNase I footprint experiments. The sequence required for MAF1 binding is very similar to the MEF-3 motif, which is an element of the skeletal muscle-specific enhancer of the cardiac troponin C gene. Because MAF1 and MEF-3 are closely related in both recognition sequence and distribution, MAF1 and MEF-3 probably represent the same nuclear factor which may play an important role in muscle gene transcription. Thus, the muscle-specific induction of the aldolase A gene is governed by muscle-specific MEF-2 and existing MEF-3 (MAF1). | lld:pubmed |
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| pubmed-article:8413246 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8413246 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8413246 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8413246 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8413246 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8413246 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8413246 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8413246 | pubmed:author | pubmed-author:YamamotoII | lld:pubmed |
| pubmed-article:8413246 | pubmed:author | pubmed-author:MukaiTT | lld:pubmed |
| pubmed-article:8413246 | pubmed:author | pubmed-author:AraiYY | lld:pubmed |
| pubmed-article:8413246 | pubmed:author | pubmed-author:HidakaKK | lld:pubmed |
| pubmed-article:8413246 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8413246 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8413246 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8413246 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8413246 | pubmed:pagination | 6469-78 | lld:pubmed |
| pubmed-article:8413246 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
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| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:meshHeading | pubmed-meshheading:8413246-... | lld:pubmed |
| pubmed-article:8413246 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8413246 | pubmed:articleTitle | The MEF-3 motif is required for MEF-2-mediated skeletal muscle-specific induction of the rat aldolase A gene. | lld:pubmed |
