| pubmed-article:8406574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1123019 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:8406574 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:8406574 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8406574 | pubmed:dateCreated | 1993-11-5 | lld:pubmed |
| pubmed-article:8406574 | pubmed:abstractText | A combination of concanavalin A (Con A)-stimulated ovine lymph node (LN) cells and Chinese hamster ovarian (CHO) cells stably transfected with the ovine interleukin-2 receptor-alpha (IL-2R alpha) chain cDNA (CHO IL-2R cells) were used in a differential immunization strategy to generate several monoclonal antibodies (mAb) against the ovine IL-2R alpha chain. The specificity of one of the mAb, designated mAb 9-14, for the ovine IL-2R alpha chain was demonstrated by its reactivity with Con A-stimulated LN cells and CHO IL-2R cells, immunoprecipitation of a 47,000 MW protein from CHO IL-2R cells and inhibition of IL-2-dependent proliferation of Con A-stimulated ovine LN cells. Examination of IL-2R alpha chain expression on resting lamb peripheral blood lymphocyte populations showed a high frequency of IL-2R alpha chain expression on CD4 T cells but not on CD8 T cells, CD45RA+ cells or gamma delta T cells, which comprise up to 60% of lamb peripheral blood T cells. The kinetics of IL-2R alpha chain induction on Con A-stimulated peripheral blood alpha beta and gamma delta T cells was compared. A rapid induction of IL-2R alpha chain expression on precultured gamma delta T cells but not alpha beta T cells was observed within 6 hr of Con A stimulation. A preculturing period was required to 'prime' gamma delta T cells for rapid responsiveness to Con A. Using appropriate inhibitors, we demonstrated that both transcription and translation events were required for rapid IL-2R expression on precultured gamma delta T cells and therefore the 'priming' of gamma delta T cells by in vitro culture did not involve an accumulation of IL-2R alpha chain mRNA or preformed receptors within these cells. | lld:pubmed |
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| pubmed-article:8406574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8406574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8406574 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8406574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8406574 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8406574 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8406574 | pubmed:author | pubmed-author:BrandonM RMR | lld:pubmed |
| pubmed-article:8406574 | pubmed:author | pubmed-author:NashA DAD | lld:pubmed |
| pubmed-article:8406574 | pubmed:author | pubmed-author:VerhagenA MAM | lld:pubmed |
| pubmed-article:8406574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8406574 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:8406574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8406574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8406574 | pubmed:pagination | 471-8 | lld:pubmed |
| pubmed-article:8406574 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8406574 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8406574 | pubmed:articleTitle | Characterization of the ovine interleukin-2 receptor-alpha chain: differential induction on precultured alpha beta and gamma delta T cells. | lld:pubmed |
| pubmed-article:8406574 | pubmed:affiliation | Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Australia. | lld:pubmed |
| pubmed-article:8406574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8406574 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8406574 | lld:pubmed |
