| pubmed-article:8402133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8402133 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:8402133 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8402133 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8402133 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8402133 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:8402133 | lifeskim:mentions | umls-concept:C0893636 | lld:lifeskim |
| pubmed-article:8402133 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8402133 | pubmed:dateCreated | 1993-11-22 | lld:pubmed |
| pubmed-article:8402133 | pubmed:abstractText | Phospholipase activation may play an important role in ulcerative colitis. This hypothesis was tested by evaluating the effect of two non-selective phospholipase (PL) A2 inhibitors, quinacrine and p-bromophenacyl-bromide (pBPB), on acetic acid-induced colitis in the rat. The calcium antagonist verapamil, which may also act as a PLA2 inhibitor, was also tested. Acute colitis was induced in an isolated colonic segment by instillation of 4 per cent acetic acid for 15 s; this induces a uniform colitis after 4 days. The severity of colitis was evaluated histologically, by measuring myeloperoxidase (MPO) activity and by determining plasma exudation into the lumen of the colon (permeability) with 125I-labelled albumin given intravenously. All three putative PLA2 inhibitors tested were found to prevent the development of colitis. Intravenous administration of quinacrine 10 mg kg-1 at 30 min before instillation of acetic acid resulted in a normal mucosal appearance, normal MPO activity and a significantly reduced increase in plasma exudation into the colon. A similar effect was achieved using verapamil. Intracolonic administration of either quinacrine or pBPB also prevented acetic acid-induced colitis. However, three doses, starting immediately after acetic acid administration and repeated on the first and second days, were needed to achieve this, whereas one dose produced only a partial effect. PLA2 may play an important role in acetic acid-induced colitis and inhibition of its activity may offer an alternative mode of treatment in ulcerative colitis. | lld:pubmed |
| pubmed-article:8402133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8402133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8402133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8402133 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8402133 | pubmed:issn | 0007-1323 | lld:pubmed |
| pubmed-article:8402133 | pubmed:author | pubmed-author:BengmarkSS | lld:pubmed |
| pubmed-article:8402133 | pubmed:author | pubmed-author:AnderssonRR | lld:pubmed |
| pubmed-article:8402133 | pubmed:author | pubmed-author:WillénRR | lld:pubmed |
| pubmed-article:8402133 | pubmed:author | pubmed-author:Ar'RajabAA | lld:pubmed |
| pubmed-article:8402133 | pubmed:author | pubmed-author:FabiaRR | lld:pubmed |
| pubmed-article:8402133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8402133 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:8402133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8402133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8402133 | pubmed:pagination | 1199-204 | lld:pubmed |
| pubmed-article:8402133 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8402133 | pubmed:meshHeading | pubmed-meshheading:8402133-... | lld:pubmed |
| pubmed-article:8402133 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8402133 | pubmed:articleTitle | Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat. | lld:pubmed |
| pubmed-article:8402133 | pubmed:affiliation | Department of Surgery, Lund University, Sweden. | lld:pubmed |
| pubmed-article:8402133 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8402133 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8402133 | lld:pubmed |
