| pubmed-article:8401944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0038351 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0034791 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0064465 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8401944 | lifeskim:mentions | umls-concept:C0109741 | lld:lifeskim |
| pubmed-article:8401944 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8401944 | pubmed:dateCreated | 1993-11-2 | lld:pubmed |
| pubmed-article:8401944 | pubmed:abstractText | 1. The cholecystokinin receptors mediating motor responses in a novel smooth muscle preparation from the corpus region of the guinea-pig stomach have been characterized by use of five agonist peptides and the antagonists CI-988, L-365,260 and devazepide. 2. Mucosa-denuded strips of circular muscle were contracted in a concentration-dependent manner by the five cholecystokinin (CCK)-related peptides CCK-8S, pentagastrin, gastrin-I, CCK-8US and CCK-4. 3. CI-988 was a powerful antagonist of the response to pentagastrin with an affinity (pKB = 9.49) similar to that obtained in CCKB receptor binding assays. With CCK-8S as the agonist, CI-988 was approximately 1000 fold less powerful as an antagonist. 4. Devazepide powerfully blocked responses to CCK-8S with an affinity (pKB = 9.54) that was in agreement with reported functional data obtained in pancreatic amylase secretion studies, a system exhibiting CCKA receptor activity. Devazepide displayed lower affinity against pentagastrin than against CCK-8S. 5. CI-988 blocked responses to pentagastrin in an insurmountable manner in the presence of 3 nM devazepide; a concentration previously shown to block the CCKA receptor. The nature of the antagonism observed with L-365,260 was unaltered by the presence of devazepide. 6. The guinea-pig stomach corpus smooth muscle preparation contains both subtypes of CCK receptor and will be useful as a pharmacological tool for investigating the functional effects of novel CCK ligands. | lld:pubmed |
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| pubmed-article:8401944 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8401944 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8401944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8401944 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8401944 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:8401944 | pubmed:author | pubmed-author:WoodruffG NGN | lld:pubmed |
| pubmed-article:8401944 | pubmed:author | pubmed-author:McKnightA TAT | lld:pubmed |
| pubmed-article:8401944 | pubmed:author | pubmed-author:BoyleS JSJ | lld:pubmed |
| pubmed-article:8401944 | pubmed:author | pubmed-author:TangK WKW | lld:pubmed |
| pubmed-article:8401944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8401944 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:8401944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8401944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8401944 | pubmed:pagination | 913-7 | lld:pubmed |
| pubmed-article:8401944 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8401944 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8401944 | pubmed:articleTitle | Characterization of CCK receptors in a novel smooth muscle preparation from the guinea-pig stomach by use of the selective antagonists CI-988, L-365,260 and devazepide. | lld:pubmed |
| pubmed-article:8401944 | pubmed:affiliation | Parke-Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge. | lld:pubmed |
| pubmed-article:8401944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8401944 | pubmed:publicationType | In Vitro | lld:pubmed |
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