| pubmed-article:8396680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0205725 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0019381 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0079506 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:8396680 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:8396680 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8396680 | pubmed:dateCreated | 1993-10-12 | lld:pubmed |
| pubmed-article:8396680 | pubmed:abstractText | In order to clarify antigenic variations among various isolates of human herpesvirus 6 (HHV-6) and cross-reactivity among HHV-6, HHV-7, and human cytomegalovirus (HCMV) in the T-cell immune response, the antigenic specificity of the proliferative response mediated by 232 CD4+ human T-cell clones directed against HHV-6, HHV-7, or HCMV was examined. The results obtained were as follows. (i) Although the majority of T-cell clones directed against HHV-6 proliferated in response to stimulation with all strains of HHV-6 used (U1102, Z29, SF, and HST), 7% (8 of 122) of the T-cell clones showed distinct patterns of proliferative response against strain U1102 (group A) and other strains of HHV-6 (group B). (ii) Of 99 T-cell clones, 71 showed a distinct proliferative response to HHV-6 and HHV-7, whereas 28 proliferated in response to stimulation with both HHV-6 and HHV-7. (iii) A small number of T-cell clones (9 of 232) showed cross-reactivity against HHV-6 and HCMV, and 2 of the 232 clones were reactive with HCMV as well as with HHV-6 and HHV-7. (iv) The specificity of gamma interferon production by T-cell clones following the stimulation with virus antigen was identical to that of their proliferative response. These data thus indicate the presence of antigenic variations among isolates of HHV-6 and also epitopes common to HHV-6 and HHV-7 and to HHV-6, HHV-7, and HCMV which are recognized by CD4+ T cells. | lld:pubmed |
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| pubmed-article:8396680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8396680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396680 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8396680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8396680 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8396680 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8396680 | pubmed:author | pubmed-author:FujitaSS | lld:pubmed |
| pubmed-article:8396680 | pubmed:author | pubmed-author:YasukawaMM | lld:pubmed |
| pubmed-article:8396680 | pubmed:author | pubmed-author:FurukawaMM | lld:pubmed |
| pubmed-article:8396680 | pubmed:author | pubmed-author:YakushijinYY | lld:pubmed |
| pubmed-article:8396680 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8396680 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:8396680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8396680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8396680 | pubmed:pagination | 6259-64 | lld:pubmed |
| pubmed-article:8396680 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8396680 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8396680 | pubmed:articleTitle | Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus. | lld:pubmed |
| pubmed-article:8396680 | pubmed:affiliation | First Department of Internal Medicine, Ehime University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:8396680 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8396680 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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