| pubmed-article:8396631 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0010097 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0162512 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0206056 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C1879743 | lld:lifeskim |
| pubmed-article:8396631 | lifeskim:mentions | umls-concept:C0036557 | lld:lifeskim |
| pubmed-article:8396631 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8396631 | pubmed:dateCreated | 1993-10-14 | lld:pubmed |
| pubmed-article:8396631 | pubmed:abstractText | The effects of some sedative drugs on the extracellular concentration of histamine (HA) in the striatum of conscious freely moving rats were examined by in vivo microdialysis coupled with high-performance liquid chromatography-fluorometry. The HA output did not significantly change until 4 hr after intraperitoneal saline injection. Pentobarbital (46 mg/kg i.p.) significantly decreased the HA output by 76% at 0.5 to 1 hr after treatment. Muscimol (5 mg/kg i.p.) and diazepam (20 mg/kg i.p.) also significantly decreased the HA output at 0.5 to 1.5 hr after treatment. delta 9-Tetrahydrocannabinol (5 mg/kg i.p.) induced biphasic changes in the HA output, i.e., a significant increase and a significant decrease were observed at 0 to 0.5 hr and 1.5 to 2.5 hr after treatment, respectively. Reserpine (5 mg/kg i.p.) significantly increased the HA output by 47% to 58% at 0 to 2 hr after treatment. The HA output decreased to a level below 10% of the basal value by 4 hr after treatment with (S)-alpha-fluoromethylhistidine (77 mg/kg i.p.). Reserpine slightly restored the HA output (to about 25% of the original basal value). These results, taken together with our previous results, suggest the following: 1) pentobarbital, muscimol and diazepam inhibit HA release; 2) tetrahydrocannabinol initially increases HA release for a short period but markedly decreases the release thereafter; and 3) reserpine increases the extracellular HA concentration probably as a result of inhibition of its elimination. | lld:pubmed |
| pubmed-article:8396631 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8396631 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396631 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8396631 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8396631 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:8396631 | pubmed:author | pubmed-author:SaekiKK | lld:pubmed |
| pubmed-article:8396631 | pubmed:author | pubmed-author:OishiRR | lld:pubmed |
| pubmed-article:8396631 | pubmed:author | pubmed-author:ChikaiTT | lld:pubmed |
| pubmed-article:8396631 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8396631 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:8396631 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8396631 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8396631 | pubmed:pagination | 1277-81 | lld:pubmed |
| pubmed-article:8396631 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:meshHeading | pubmed-meshheading:8396631-... | lld:pubmed |
| pubmed-article:8396631 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8396631 | pubmed:articleTitle | Microdialysis study of the effects of sedative drugs on extracellular histamine in the striatum of freely moving rats. | lld:pubmed |
| pubmed-article:8396631 | pubmed:affiliation | Department of Pharmacology, Okayama University Medical School, Japan. | lld:pubmed |
| pubmed-article:8396631 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8396631 | lld:pubmed |
