| pubmed-article:8396273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8396273 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:8396273 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:8396273 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:8396273 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8396273 | pubmed:issue | 5127 | lld:pubmed |
| pubmed-article:8396273 | pubmed:dateCreated | 1993-10-4 | lld:pubmed |
| pubmed-article:8396273 | pubmed:abstractText | The function of voltage-gated sodium channels that are responsible for action potential generation in mammalian brain neurons is modulated by phosphorylation by adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase (cA-PK) and by protein kinase C (PKC). Reduction of peak sodium currents by cA-PK in intact cells required concurrent activation of PKC and was prevented by blocking phosphorylation of serine 1506, a site in the inactivation gate of the channel that is phosphorylated by PKC but not by cA-PK. Replacement of serine 1506 with negatively charged amino acids mimicked the effect of phosphorylation. Conversion of the consensus sequence surrounding serine 1506 to one more favorable for cA-PK enhanced modulation of sodium currents by cA-PK. Convergent modulation of sodium channels required phosphorylation of serine 1506 by PKC accompanied by phosphorylation of additional sites by cA-PK. This regulatory mechanism may serve to integrate neuronal signals mediated through these parallel signaling pathways. | lld:pubmed |
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| pubmed-article:8396273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8396273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396273 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8396273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8396273 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8396273 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8396273 | pubmed:author | pubmed-author:WestJ WJW | lld:pubmed |
| pubmed-article:8396273 | pubmed:author | pubmed-author:CatterallW... | lld:pubmed |
| pubmed-article:8396273 | pubmed:author | pubmed-author:MurphyB JBJ | lld:pubmed |
| pubmed-article:8396273 | pubmed:author | pubmed-author:MADD | lld:pubmed |
| pubmed-article:8396273 | pubmed:author | pubmed-author:ScheuerTT | lld:pubmed |
| pubmed-article:8396273 | pubmed:author | pubmed-author:NumannRR | lld:pubmed |
| pubmed-article:8396273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8396273 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:8396273 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:8396273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8396273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8396273 | pubmed:pagination | 1439-42 | lld:pubmed |
| pubmed-article:8396273 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8396273 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8396273 | pubmed:articleTitle | Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase. | lld:pubmed |
| pubmed-article:8396273 | pubmed:affiliation | Department of Pharmacology, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:8396273 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8396273 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8396273 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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