| pubmed-article:8395025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C0031678 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C1704970 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C0083009 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:8395025 | lifeskim:mentions | umls-concept:C0335218 | lld:lifeskim |
| pubmed-article:8395025 | pubmed:issue | 6440 | lld:pubmed |
| pubmed-article:8395025 | pubmed:dateCreated | 1993-9-21 | lld:pubmed |
| pubmed-article:8395025 | pubmed:abstractText | In non-excitable cells, release of Ca2+ from the inositol 1,4,5-trisphosphate (InsP3)-sensitive store can activate Ca2+ entry. Very little is known about the signal mechanism relating store emptying to plasma membrane Ca2+ influx. It has been suggested that the signal may be either a diffusible messenger like an inositol phosphate, or the InsP3 receptor itself, which, by physically coupling to some component of Ca2+ entry in the plasma membrane, may link store release to Ca2+ entry. The nature of the Ca2+ entry pathway is also unclear. Only in mast cells has a very selective Ca2+ current been observed after store emptying. Activation of exogenous 5-hydroxytryptamine (5-HT) receptors expressed in Xenopus oocytes or direct injection of InsP3 evokes Ca2+ entry activated by InsP3 pool depletion. Here we investigate the nature of this influx pathway and find a current activated by pool depletion. This has an unusual selectivity in that it is more permeable to Ca2+ ions than to other divalent cations (Ba2+, Sr2+ or Mn2+). Moreover, a K+ permeability is also stimulated after pool depletion. The activation of this store depletion current involves both a phosphatase and an unidentified diffusible messenger. Both the Ca2+ entry pathway and the activating factors found here may be relevant to pool-depleted Ca2+ entry in a variety of non-excitable cells. | lld:pubmed |
| pubmed-article:8395025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8395025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8395025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8395025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8395025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8395025 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8395025 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8395025 | pubmed:author | pubmed-author:StühmerWW | lld:pubmed |
| pubmed-article:8395025 | pubmed:author | pubmed-author:TerlauHH | lld:pubmed |
| pubmed-article:8395025 | pubmed:author | pubmed-author:ParekhA BAB | lld:pubmed |
| pubmed-article:8395025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8395025 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:8395025 | pubmed:volume | 364 | lld:pubmed |
| pubmed-article:8395025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8395025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8395025 | pubmed:pagination | 814-8 | lld:pubmed |
| pubmed-article:8395025 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8395025 | pubmed:meshHeading | pubmed-meshheading:8395025-... | lld:pubmed |
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| pubmed-article:8395025 | pubmed:meshHeading | pubmed-meshheading:8395025-... | lld:pubmed |
| pubmed-article:8395025 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8395025 | pubmed:articleTitle | Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger. | lld:pubmed |
| pubmed-article:8395025 | pubmed:affiliation | Max-Planck-Institute for Biophysical Chemistry, Department of Membrane Biophysics, Göttingen, Germany. | lld:pubmed |
| pubmed-article:8395025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8395025 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8395025 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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