| pubmed-article:8376962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0011220 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0057317 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0007673 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8376962 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8376962 | pubmed:dateCreated | 1993-10-18 | lld:pubmed |
| pubmed-article:8376962 | pubmed:abstractText | None of the mutations so far discovered in several hepatitis delta virus (HDV) isolates appears to determine important changes in HDV specific protein (HDAg) expression, except for a putative mutation at nucleotide 1012 converting an amber stop codon (TAG) to a codon for tryptophan (TGG). Here we present the characterization of an HDV obtained from the liver of a woodchuck inoculated with sera from fulminant HDV patients in Central African Republic (CAR). By restriction enzyme analysis and sequencing of HDAg-coding region cDNA clones, we found that this HDV isolate bears a novel mutation (T to A) at nucleotide 1013 which converts the amber stop codon (TAG) to a codon for lysine (AAG). Comparison of these nucleotide sequences with those available from American, Japanese, Taiwanese, French, Italian and Nauru isolates showed a variability of 1.7 to 21.5% and 1.9 to 28.7% at the nucleic acid and amino acid levels, respectively. The HDAg-encoding sequence of the CAR isolate is closely related to that of the Italian HDV isolate. The in vitro expression of this HDV isolate resulted in a unique HDAg species (28K) which was identical with that characterized in vivo. | lld:pubmed |
| pubmed-article:8376962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8376962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376962 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8376962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8376962 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8376962 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:VitvitskiLL | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:TrépoCC | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:HantzOO | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:LamelinJ PJP | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:ParamoCC | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:CovaLL | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:LesbordesJ... | lld:pubmed |
| pubmed-article:8376962 | pubmed:author | pubmed-author:TangJ RJR | lld:pubmed |
| pubmed-article:8376962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8376962 | pubmed:volume | 74 ( Pt 9) | lld:pubmed |
| pubmed-article:8376962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8376962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8376962 | pubmed:pagination | 1827-35 | lld:pubmed |
| pubmed-article:8376962 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:meshHeading | pubmed-meshheading:8376962-... | lld:pubmed |
| pubmed-article:8376962 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8376962 | pubmed:articleTitle | Discovery of a novel point mutation changing the HDAg expression of a hepatitis delta virus isolate from Central African Republic. | lld:pubmed |
| pubmed-article:8376962 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale (INSERM) U 271, Lyon, France. | lld:pubmed |
| pubmed-article:8376962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8376962 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8376962 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8376962 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8376962 | lld:pubmed |
