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pubmed-article:8361328pubmed:dateCreated1993-9-30lld:pubmed
pubmed-article:8361328pubmed:abstractTextThe effect of ouabain on urinary Na and K excretion was compared with that of aldosterone by injecting 0.1 or 0.5 mg ouabain or 0.25 micrograms aldosterone. The administration of 0.25 micrograms aldosterone caused sodium-retention without kaliuresis, whereas the administration of 0.5 mg ouabain caused kaliuresis without sodium-retention. These results indicate that ouabain is a kaliuretic agent. The effect of a combination of aldosterone and ouabain was evaluated by injecting 0.25 micrograms aldosterone simultaneously with 0.1 or 0.5 mg ouabain. The combination of aldosterone and ouabain caused both sodium-retention and kaliuresis. These results indicate that ouabain works synergistically with aldosterone to increase mineralocorticoid action by inducing K depletion from the cells in various tissues.lld:pubmed
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pubmed-article:8361328pubmed:authorpubmed-author:YazakiYYlld:pubmed
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pubmed-article:8361328pubmed:pagination975-80lld:pubmed
pubmed-article:8361328pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8361328pubmed:year1993lld:pubmed
pubmed-article:8361328pubmed:articleTitleOuabain causes kaliuresis and works synergistically with aldosterone in vivo.lld:pubmed
pubmed-article:8361328pubmed:affiliationThird Department of Internal Medicine, University of Tokyo Faculty of Medicine, Japan.lld:pubmed
pubmed-article:8361328pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8361328pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8361328pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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